Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNQ3 | O43525 | 1/20 | 0.64 |
| ▸ | KCNQ2 | O43526 | 1/20 | 0.64 |
| ▸ | KCNQ4 | P56696 | 1/20 | 0.64 |
| ▸ | KCNMA1 | Q12791 | 1/20 | 0.64 |
| ▸ | KCNQ5 | Q9NR82 | 1/20 | 0.64 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | IDO1 | P14902 | 2/20 | 0.43 |
| ▸ | CBX7 | O95931 | 2/20 | 0.41 |
| ▸ | CDYL | Q9Y232 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | BRD4 | O60885 | 3/20 | 0.40 |
| ▸ | ELOVL6 | Q9H5J4 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | ADAMTS5 | Q9UNA0 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | CDYL2 | Q8N8U2 | 1/20 | 0.37 |
| ▸ | CDY1; CDY1B | Q9Y6F8 | 1/20 | 0.37 |
| ▸ | ESRRA | P11474 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5858002 | 0.91 | KCNQ3 (0.74) | KCNQ3KCNQ2KCNQ4KCNMA1KCNQ5 | |
| SCHEMBL2495455 | 0.90 | KCNQ3 (0.51) | KCNQ3KCNQ2KCNQ4KCNMA1KCNQ5 | |
| SCHEMBL2495393 | 0.89 | KMT2A (0.57) | KCNQ3KCNQ2KCNQ4KCNMA1KCNQ5 | |
| SCHEMBL2499035 | 0.85 | KMT2A (0.53) | KCNQ3KCNQ2KCNQ4KCNMA1KCNQ5 | |
| SCHEMBL2497429 | 0.83 | CBX7 (0.52) | KCNQ3KCNQ2KCNQ4KCNMA1KCNQ5 | |
| SCHEMBL8097511 | 0.83 | KCNQ3 (0.46) | KCNQ3KCNQ2KCNQ4KCNMA1KCNQ5 | |
| SCHEMBL2497604 | 0.83 | KMT2A (0.51) | KCNQ3KCNQ2KCNQ4KCNMA1KCNQ5 | |
| SCHEMBL5860255 | 0.82 | KMT2A (0.50) | KCNQ3KCNQ2KCNQ4KCNMA1KCNQ5 | |
| SCHEMBL27402562 | 0.81 | BRD4 (0.48) | KCNQ3KCNQ2KCNQ4KCNMA1KCNQ5 | |
| SCHEMBL1464565 | 0.81 | KMT2A (0.72) | KCNQ3KCNQ2KCNQ4KCNMA1KCNQ5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0747354-B1 | 3-Substituted oxindole derivatives as potassium channel modulators | BRISTOL MYERS SQUIBB CO (US) | 2000-08-16 | — | — | EP | disclosed |
| US-5602169-A | USEFUL IN REDUCING NEURONAL DAMAGE DURING ISCHEMIC STROKE | BRISTOL-MYERS SQUIBB COMPANY (US) | 1997-02-11 | — | — | US | disclosed |
| US-5565483-A | ADMINISTERING AS THERAPY FOR ISCHEMIA, CONVULSIONS OR ASTHMA | BRISTOL-MYERS SQUIBB COMPANY (US) | 1996-10-15 | — | — | US | disclosed |