Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 10/20 | 0.45 |
| ▸ | PIK3CA | P42336 | 8/20 | 0.45 |
| ▸ | MTOR | P42345 | 5/20 | 0.45 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.45 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.45 |
| ▸ | JAK1 | P23458 | 1/20 | 0.35 |
| ▸ | FPR2 | P25090 | 1/20 | 0.34 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | GLA | P06280 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | KIF18A | Q8NI77 | 2/20 | 0.34 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.33 |
| ▸ | KDR | P35968 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8097098 | 0.89 | PIK3CA (0.46) | PIK3CDPIK3CAMTORPIK3CBPIK3CG | |
| SCHEMBL8090843 | 0.86 | PIK3CA (0.45) | PIK3CDPIK3CAMTORPIK3CBPIK3CG | |
| SCHEMBL8094369 | 0.86 | PIK3CD (0.44) | PIK3CDPIK3CAMTORPIK3CBPIK3CG | |
| SCHEMBL8099455 | 0.83 | PIK3CD (0.47) | PIK3CDPIK3CAMTORPIK3CBPIK3CG | |
| SCHEMBL8099039 | 0.81 | PIK3CD (0.49) | PIK3CDPIK3CAMTORPIK3CBPIK3CG | |
| SCHEMBL3934555 | 0.80 | MTOR (0.58) | PIK3CDPIK3CAMTORPIK3CBPIK3CG | |
| SCHEMBL8098310 | 0.80 | PIK3CD (0.47) | PIK3CDPIK3CAMTORPIK3CBPIK3CG | |
| SCHEMBL8084799 | 0.80 | PIK3CA (0.51) | PIK3CDPIK3CAMTORPIK3CBPIK3CG | |
| SCHEMBL8091933 | 0.79 | FPR2 (0.39) | PIK3CDPIK3CAMTORPIK3CBPIK3CG | |
| SCHEMBL8082039 | 0.79 | PIK3CD (0.46) | PIK3CDPIK3CAMTORPIK3CBPIK3CG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009007748-A2 | TRISUBSTITUTED PYRIMIDINE DERIVATIVES FOR THE TREATMENT OF PROLIFERATIVE DISEASES | ASTRAZENECA AB (SE) | 2009-01-15 | — | — | WO | disclosed |