Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.49 |
| ▸ | PTAFR | P25105 | 10/20 | 0.47 |
| ▸ | IKBKB | O14920 | 1/20 | 0.44 |
| ▸ | FLT4 | P35916 | 2/20 | 0.43 |
| ▸ | FES | P07332 | 1/20 | 0.43 |
| ▸ | RET | P07949 | 1/20 | 0.43 |
| ▸ | MARK3 | P27448 | 1/20 | 0.43 |
| ▸ | TYK2 | P29597 | 1/20 | 0.43 |
| ▸ | SYK | P43405 | 1/20 | 0.43 |
| ▸ | CLK2 | P49760 | 1/20 | 0.43 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.43 |
| ▸ | HRH1 | P35367 | 2/20 | 0.42 |
| ▸ | TBXAS1 | P24557 | 4/20 | 0.41 |
| ▸ | CDK2 | P24941 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL810402 | 0.89 | IKBKB (0.46) | HRH4PTAFRIKBKB | |
| SCHEMBL3825375 | 0.83 | IKBKB (0.58) | PTAFRIKBKBFLT4CDK2 | |
| SCHEMBL9147482 | 0.82 | BCL6 (0.53) | HRH4PTAFRFLT4CDK2 | |
| SCHEMBL809903 | 0.81 | NAMPT (0.46) | HRH4IKBKB | |
| SCHEMBL20095479 | 0.80 | IKBKB (0.50) | IKBKB | |
| SCHEMBL9147488 | 0.80 | NPC1 (0.47) | HRH4PTAFRFLT4CDK2 | |
| SCHEMBL11166906 | 0.78 | CDK2 (0.52) | FLT4CDK2 | |
| SCHEMBL504319 | 0.78 | HRH4 (0.59) | HRH4PTAFRFLT4FESRET | |
| SCHEMBL9149002 | 0.77 | BCL6 (0.62) | HRH4 | |
| SCHEMBL7098728 | 0.77 | CYP1A2 (0.53) | IKBKB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1397355-B1 | PYRIDYL CYANOGUANIDINE COMPOUNDS | LEO PHARMA AS (DK) | 2009-09-09 | — | — | EP | claimed |
| EP-2394649-A1 | PHARMACEUTICAL COMPOSITIONS CONTAINING PYRIDYL CYANOGUANIDINES, PREPARATION METHODS AND USES THEREOF | Tianjin Hemay Bio-Tech Co., Ltd. (CN) | 2011-12-14 | — | — | EP | disclosed |
| EP-1397355-B1 | PYRIDYL CYANOGUANIDINE COMPOUNDS | LEO PHARMA AS (DK) | 2009-09-09 | — | — | EP | disclosed |