Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 3/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | INSR | P06213 | 1/20 | 0.45 |
| ▸ | KDR | P35968 | 1/20 | 0.45 |
| ▸ | GSK3A | P49840 | 1/20 | 0.45 |
| ▸ | GSK3B | P49841 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | SGMS2 | Q8NHU3 | 1/20 | 0.44 |
| ▸ | CDK2 | P24941 | 1/20 | 0.44 |
| ▸ | FLT4 | P35916 | 1/20 | 0.44 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.43 |
| ▸ | PTAFR | P25105 | 1/20 | 0.42 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9147482 | 0.88 | BCL6 (0.53) | NPC1MEN1KMT2ARAB9AALDH1A1 | |
| SCHEMBL9151640 | 0.82 | BCL6 (0.46) | NPC1MEN1KMT2ASMN1; SMN2GAA | |
| SCHEMBL11160665 | 0.81 | LMNA (0.50) | NPC1MEN1KMT2ASMN1; SMN2RAB9A | |
| SCHEMBL9149002 | 0.81 | BCL6 (0.62) | NPC1MEN1KMT2ASMN1; SMN2RAB9A | |
| SCHEMBL11166906 | 0.80 | CDK2 (0.52) | NPC1MEN1KMT2ASMN1; SMN2RAB9A | |
| SCHEMBL11166666 | 0.80 | MEN1 (0.51) | NPC1MEN1KMT2ASMN1; SMN2RAB9A | |
| SCHEMBL809770 | 0.80 | HRH4 (0.49) | CDK2FLT4HRH4PTAFR | |
| SCHEMBL8917912 | 0.80 | IKBKB (0.63) | NPC1MEN1KMT2ARAB9ACDK2 | |
| SCHEMBL7356177 | 0.79 | HRH4 (0.54) | MEN1KMT2AHRH4NOTUMABCC9 | |
| SCHEMBL6615293 | 0.78 | CYP11B1 (0.57) | MEN1KMT2ASMN1; SMN2RAB9ALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0655057-A1 | CYANOGUANIDINES AS POTASSIUM CHANNEL BLOCKERS. | UPJOHN CO (US) | 1995-05-31 | — | — | EP | claimed |
| WO-1994004499-A1 | CYANOGUANIDINES AS POTASSIUM CHANNEL BLOCKERS | THE UPJOHN COMPANY (US) | 1994-03-03 | — | — | WO | claimed |
| EP-0655057-A1 | CYANOGUANIDINES AS POTASSIUM CHANNEL BLOCKERS. | UPJOHN CO (US) | 1995-05-31 | — | — | EP | disclosed |
| WO-1994004499-A1 | CYANOGUANIDINES AS POTASSIUM CHANNEL BLOCKERS | THE UPJOHN COMPANY (US) | 1994-03-03 | — | — | WO | disclosed |