Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 6/20 | 0.48 |
| ▸ | PIK3CA | P42336 | 6/20 | 0.48 |
| ▸ | MTOR | P42345 | 4/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.42 |
| ▸ | HTT | P42858 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | LDLR | P01130 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8101525 | 0.86 | TP53 (0.51) | PIK3CDPIK3CAMTORALDH1A1KMT2A | |
| SCHEMBL8106097 | 0.85 | PIK3CA (0.46) | PIK3CDPIK3CAMTORALDH1A1KMT2A | |
| SCHEMBL8101524 | 0.84 | MEN1 (0.54) | PIK3CDPIK3CAMTORALDH1A1KMT2A | |
| SCHEMBL8093349 | 0.84 | PIK3CD (0.48) | PIK3CDPIK3CAMTORALDH1A1NPSR1 | |
| SCHEMBL8109730 | 0.83 | PIK3CD (0.45) | PIK3CDPIK3CAMTORALDH1A1KMT2A | |
| SCHEMBL8099639 | 0.83 | PIK3CA (0.48) | PIK3CDPIK3CAMTORNPSR1KMT2A | |
| SCHEMBL3055829 | 0.82 | MTOR (0.70) | PIK3CDPIK3CAMTORCYP3A4CYP2C9 | |
| SCHEMBL8095869 | 0.82 | PIK3CA (0.46) | PIK3CDPIK3CAMTORALDH1A1NPSR1 | |
| SCHEMBL8099598 | 0.82 | PIK3CD (0.45) | PIK3CDPIK3CAMTORALDH1A1KMT2A | |
| SCHEMBL8103980 | 0.82 | PIK3CA (0.47) | PIK3CDPIK3CAMTORALDH1A1NPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009007749-A2 | TRISUBSTITUTED PYRIMIDINE DERIVATIVES FOR THE TREATMENT OF PROLIFERATIVE DISEASES | ASTRAZENECA AB (SE) | 2009-01-15 | — | — | WO | disclosed |