Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 2/20 | 0.43 |
| ▸ | MTOR | P42345 | 2/20 | 0.43 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.43 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.43 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.43 |
| ▸ | NAMPT | P43490 | 8/20 | 0.41 |
| ▸ | ROCK2 | O75116 | 5/20 | 0.38 |
| ▸ | KIF18A | Q8NI77 | 2/20 | 0.34 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.33 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.33 |
| ▸ | FEN1 | P39748 | 1/20 | 0.33 |
| ▸ | ABL1 | P00519 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8099656 | 0.80 | PIK3CD (0.39) | PIK3CAMTORPIK3CDPIK3CBPIK3CG | |
| SCHEMBL8098310 | 0.74 | PIK3CD (0.47) | PIK3CAMTORPIK3CDPIK3CBPIK3CG | |
| SCHEMBL8082039 | 0.73 | PIK3CD (0.46) | PIK3CAMTORPIK3CDPIK3CBPIK3CG | |
| SCHEMBL8084799 | 0.72 | PIK3CA (0.51) | PIK3CAMTORPIK3CDPIK3CBPIK3CG | |
| SCHEMBL8090008 | 0.72 | PIK3CA (0.51) | PIK3CAMTORPIK3CDPIK3CBPIK3CG | |
| SCHEMBL8090843 | 0.71 | PIK3CA (0.45) | PIK3CAMTORPIK3CDPIK3CBPIK3CG | |
| SCHEMBL8099039 | 0.70 | PIK3CD (0.49) | PIK3CAMTORPIK3CDPIK3CBPIK3CG | |
| SCHEMBL8095771 | 0.70 | PIK3CD (0.43) | PIK3CAMTORPIK3CDPIK3CBPIK3CG | |
| SCHEMBL8100894 | 0.70 | PIK3CD (0.37) | PIK3CAMTORPIK3CDPIK3CBPIK3CG | |
| SCHEMBL8098964 | 0.70 | PIK3CD (0.33) | PIK3CAMTORPIK3CDPIK3CBPIK3CG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009007748-A2 | TRISUBSTITUTED PYRIMIDINE DERIVATIVES FOR THE TREATMENT OF PROLIFERATIVE DISEASES | ASTRAZENECA AB (SE) | 2009-01-15 | — | — | WO | disclosed |