Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 3/20 | 0.39 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.39 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.39 |
| ▸ | MTOR | P42345 | 1/20 | 0.39 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.39 |
| ▸ | NAMPT | P43490 | 8/20 | 0.38 |
| ▸ | ROCK2 | O75116 | 5/20 | 0.37 |
| ▸ | KDM1A | O60341 | 1/20 | 0.35 |
| ▸ | MAOA | P21397 | 1/20 | 0.35 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.34 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.34 |
| ▸ | FEN1 | P39748 | 1/20 | 0.34 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.33 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.33 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.33 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.33 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8093447 | 0.86 | MTOR (0.43) | PIK3CDPIK3CAPIK3CBMTORPIK3CG | |
| SCHEMBL8081909 | 0.85 | CA12 (0.41) | PIK3CDPIK3CAPIK3CBMTORPIK3CG | |
| SCHEMBL8091695 | 0.83 | CA12 (0.41) | PIK3CDPIK3CAPIK3CBMTORPIK3CG | |
| SCHEMBL8090008 | 0.82 | PIK3CA (0.51) | PIK3CDPIK3CAPIK3CBMTORPIK3CG | |
| SCHEMBL8099455 | 0.81 | PIK3CD (0.47) | PIK3CDPIK3CAPIK3CBMTORPIK3CG | |
| SCHEMBL8093006 | 0.81 | PIK3CD (0.42) | PIK3CDPIK3CAPIK3CBMTORPIK3CG | |
| SCHEMBL8097552 | 0.81 | PIK3CA (0.44) | PIK3CDPIK3CAPIK3CBMTORPIK3CG | |
| SCHEMBL8084799 | 0.81 | PIK3CA (0.51) | PIK3CDPIK3CAPIK3CBMTORPIK3CG | |
| SCHEMBL8098313 | 0.80 | PIK3CA (0.43) | PIK3CDPIK3CAPIK3CBMTORPIK3CG | |
| SCHEMBL8081910 | 0.80 | PIK3CD (0.43) | PIK3CDPIK3CAPIK3CBMTORPIK3CG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009007748-A2 | TRISUBSTITUTED PYRIMIDINE DERIVATIVES FOR THE TREATMENT OF PROLIFERATIVE DISEASES | ASTRAZENECA AB (SE) | 2009-01-15 | — | — | WO | disclosed |