Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 6/20 | 0.48 |
| ▸ | PIK3CD | O00329 | 4/20 | 0.48 |
| ▸ | MTOR | P42345 | 4/20 | 0.46 |
| ▸ | KDR | P35968 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | GHSR | Q92847 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.39 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.39 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.39 |
| ▸ | KIT | P10721 | 1/20 | 0.39 |
| ▸ | NAMPT | P43490 | 1/20 | 0.39 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.39 |
| ▸ | PTPN7 | P35236 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8215121 | 0.93 | PIK3CA (0.56) | PIK3CAPIK3CDMTORKDRMEN1 | |
| SCHEMBL8091889 | 0.91 | PIK3CA (0.48) | PIK3CAPIK3CDMTORKDRMEN1 | |
| SCHEMBL8216933 | 0.90 | PIK3CA (0.45) | PIK3CAPIK3CDMTORKDRMEN1 | |
| SCHEMBL8098329 | 0.90 | PIK3CA (0.55) | PIK3CAPIK3CDMTORKDRPIK3CG | |
| SCHEMBL11926139 | 0.89 | PIK3CA (0.47) | PIK3CAPIK3CDMTORKDRMEN1 | |
| SCHEMBL8206190 | 0.85 | PIK3CD (0.43) | PIK3CAPIK3CDMTORMEN1KMT2A | |
| SCHEMBL8215045 | 0.85 | PIK3CA (0.54) | PIK3CAPIK3CDMTORKDRGHSR | |
| SCHEMBL8211601 | 0.85 | PIK3CA (0.48) | PIK3CAPIK3CDMTORKDRMEN1 | |
| SCHEMBL8084637 | 0.85 | CA12 (0.45) | PIK3CAPIK3CDMTORMEN1KMT2A | |
| SCHEMBL8206121 | 0.84 | PIK3CA (0.62) | PIK3CAPIK3CDMTORKDRMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009007748-A2 | TRISUBSTITUTED PYRIMIDINE DERIVATIVES FOR THE TREATMENT OF PROLIFERATIVE DISEASES | ASTRAZENECA AB (SE) | 2009-01-15 | — | — | WO | disclosed |