Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 | P00915 | 3/20 | 0.43 |
| ▸ | CA2 | P00918 | 3/20 | 0.43 |
| ▸ | CA12 | O43570 | 2/20 | 0.43 |
| ▸ | CA9 | Q16790 | 2/20 | 0.43 |
| ▸ | CA4 | P22748 | 1/20 | 0.43 |
| ▸ | CA7 | P43166 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | PIK3CA | P42336 | 6/20 | 0.41 |
| ▸ | MTOR | P42345 | 3/20 | 0.41 |
| ▸ | NAMPT | P43490 | 4/20 | 0.39 |
| ▸ | PIK3CD | O00329 | 7/20 | 0.39 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.39 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.39 |
| ▸ | CNR1 | P21554 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8092289 | 0.95 | CA1 (0.41) | CA1CA2CA12CA9CA4 | |
| SCHEMBL8083160 | 0.94 | PIK3CD (0.43) | CA1CA2CA12CA9CA4 | |
| SCHEMBL8090241 | 0.90 | NAMPT (0.43) | PIK3CAMTORNAMPTPIK3CDPIK3CB | |
| SCHEMBL8083924 | 0.90 | PIK3CA (0.44) | CA1CA2CA12CA9CA4 | |
| SCHEMBL8093138 | 0.90 | NAMPT (0.40) | CA1CA2CA12CA9CA4 | |
| SCHEMBL8083027 | 0.88 | PIK3CA (0.38) | CA1CA2CA12CA9CA4 | |
| SCHEMBL8093145 | 0.88 | MAPT (0.39) | CA1CA2CA12CA9CA4 | |
| SCHEMBL8100146 | 0.88 | CA1 (0.41) | CA1CA2CA12CA9CA4 | |
| SCHEMBL8096186 | 0.88 | MAPT (0.41) | CA1CA2CA12CA9CA4 | |
| SCHEMBL8084013 | 0.88 | PIK3CA (0.41) | CA1CA2CA12CA9CA4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009007748-A2 | TRISUBSTITUTED PYRIMIDINE DERIVATIVES FOR THE TREATMENT OF PROLIFERATIVE DISEASES | ASTRAZENECA AB (SE) | 2009-01-15 | — | — | WO | disclosed |