Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDO1 | P14902 | 2/20 | 0.33 |
| ▸ | CYP11B1 | P15538 | 3/20 | 0.33 |
| ▸ | CYP11B2 | P19099 | 3/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8108412 | 0.73 | KDM4E (0.34) | — | |
| SCHEMBL8151367 | 0.73 | CYP11B1 (0.44) | IDO1CYP11B1CYP11B2 | |
| SCHEMBL8108625 | 0.71 | CYP11B1 (0.47) | CYP11B1CYP11B2 | |
| SCHEMBL5891369 | 0.68 | CYP11B1 (0.61) | IDO1CYP11B1CYP11B2 | |
| SCHEMBL8108275 | 0.68 | FNTA (0.40) | CYP11B1CYP11B2 | |
| SCHEMBL8173796 | 0.67 | CYP11B1 (0.61) | IDO1CYP11B1CYP11B2 | |
| SCHEMBL8523838 | 0.66 | CA12 (0.35) | IDO1CYP11B1CYP11B2 | |
| SCHEMBL8523840 | 0.64 | MAPT (0.36) | IDO1CYP11B1CYP11B2 | |
| SCHEMBL8148724 | 0.62 | CYP11B1 (0.39) | IDO1CYP11B1CYP11B2 | |
| SCHEMBL8098833 | 0.61 | FNTA (0.48) | CYP11B1CYP11B2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6093737-A | Inhibitors of farnesyl-protein transferase | MERCK & CO., INC. (US) | 2000-07-25 | — | — | US | disclosed |
| EP-1003374-A1 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | Merck & Co., Inc. (US) | 2000-05-31 | — | — | EP | disclosed |
| EP-1003374-A4 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | MERCK & CO INC (US) | 2000-05-31 | — | — | EP | disclosed |
| WO-1998028980-A1 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | MERCK & CO., INC. (US) | 1998-07-09 | — | — | WO | disclosed |