Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | CYP11B1 | P15538 | 2/20 | 0.36 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 4/20 | 0.34 |
| ▸ | POLB | P06746 | 3/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | NPBWR1 | P48145 | 2/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | IDO1 | P14902 | 2/20 | 0.31 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.31 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.31 |
| ▸ | CDK2 | P24941 | 1/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | PKM | P14618 | 1/20 | 0.31 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8525212 | 0.87 | FNTA (0.39) | CYP11B1CYP11B2CYP19A1 | |
| SCHEMBL8523838 | 0.81 | CA12 (0.35) | CYP11B1CYP11B2NPBWR1IDO1SLC6A2 | |
| SCHEMBL8151367 | 0.80 | CYP11B1 (0.44) | MAPTCYP11B1CYP11B2TSHRKMT2A | |
| SCHEMBL8523927 | 0.77 | FNTA (0.38) | CYP11B1CYP11B2CYP19A1 | |
| SCHEMBL5891369 | 0.72 | CYP11B1 (0.61) | MAPTCYP11B1CYP11B2ALDH1A1SMN1; SMN2 | |
| SCHEMBL8523843 | 0.72 | CYP19A1 (0.49) | CYP11B1CYP11B2ALDH1A1CYP19A1 | |
| SCHEMBL8142947 | 0.67 | CYP11B1 (0.47) | CYP11B1CYP11B2CYP19A1 | |
| SCHEMBL8148724 | 0.66 | CYP11B1 (0.39) | MAPTCYP11B1CYP11B2LMNAIDO1 | |
| SCHEMBL8173796 | 0.65 | CYP11B1 (0.61) | CYP11B1CYP11B2IDO1CYP19A1 | |
| SCHEMBL8098848 | 0.64 | IDO1 (0.33) | CYP11B1CYP11B2IDO1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5939439-A | Inhibitors of farnesyl-protein transferase | MERCK & CO., INC. (US) | 1999-08-17 | — | — | US | disclosed |