SCHEMBL8098891

SCHEMBL8098891

COc1cc(OC)nc(NC(=O)NS(=O)(=O)c2ccccc2C(O)C(C)F)n1

nearest known ligand 0.55

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
GAA P10253 1/20 0.55
CDK1 P06493 1/20 0.47
MAPT P10636 3/20 0.43
TP53 P04637 1/20 0.43
GLA P06280 1/20 0.43
KDM4E B2RXH2 1/20 0.41
NPC1 O15118 1/20 0.41
ALDH1A1 P00352 1/20 0.41
CYP1A2 P05177 1/20 0.40
KMT2A Q03164 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9739119 0.94 GAA (0.49) GAACDK1MAPTTP53GLA
SCHEMBL9126935 0.93 GAA (0.56) GAACDK1MAPTTP53GLA
SCHEMBL9127660 0.90 GAA (0.53) GAACDK1MAPTTP53GLA
SCHEMBL11130838 0.89 GAA (0.57) GAACDK1MAPTTP53GLA
SCHEMBL7806542 0.89 GAA (0.53) GAACDK1MAPTTP53GLA
SCHEMBL8097940 0.87 GAA (0.53) GAACDK1MAPTTP53GLA
SCHEMBL27535143 0.86 GAA (0.40) GAACDK1MAPTTP53GLA
SCHEMBL3679455 0.86 GAA (0.53) GAACDK1MAPTTP53GLA
SCHEMBL8613281 0.85 GAA (0.55) GAACDK1MAPTTP53GLA
SCHEMBL9267498 0.85 GAA (0.53) GAACDK1MAPTTP53GLA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0788486-B1 HERBICIDAL SULFONYL UREA DERIVATIVES KOREA RES INST CHEM TECH (KR) 2000-07-12 EP claimed
US-5461025-A Herbicides KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY (KR) 1995-10-24 US claimed
WO-1992015568-A1 BENZENESULFONYLUREA DERIVATIVES KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY (KR) 1992-09-17 WO claimed
US-20100035755-A1 METHOD OF CONTROLLING WEEDS IN A TURF GRASS BY USING SULFONYLUREA COMPOUNDS MOGHU RESEARCH CENTER LTD. (KR) 2010-02-11 US disclosed
US-5736628-A HERBICIDE KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY (KR) 1998-04-07 US disclosed
US-5461025-A Herbicides KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY (KR) 1995-10-24 US disclosed
EP-0575378-A1 BENZENESULFONYLUREA DERIVATIVES KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY (KR) 1993-12-29 EP disclosed
WO-1992015568-A1 BENZENESULFONYLUREA DERIVATIVES KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY (KR) 1992-09-17 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20100035755-A1 METHOD OF CONTROLLING WEEDS IN A TURF GRASS BY USING SULFONYLUREA COMPOUNDS NOTUM, CYP4F3, CYP4F2 GAA 337/4885CDK1 3093/4885MAPT 2872/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.