Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FFAR1 | O14842 | 2/20 | 0.57 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.57 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.51 |
| ▸ | PDCD1 | Q15116 | 2/20 | 0.50 |
| ▸ | CD274 | Q9NZQ7 | 2/20 | 0.50 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.47 |
| ▸ | PTPN5 | P54829 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 3/20 | 0.44 |
| ▸ | RAB9A | P51151 | 3/20 | 0.44 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.44 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.44 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.44 |
| ▸ | GRIA4 | P48058 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | USP2 | O75604 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8100940 | 0.86 | FFAR1 (0.55) | FFAR1AKR1B1ESR2PTPN1PTPN5 | |
| SCHEMBL8100769 | 0.84 | FFAR1 (0.56) | FFAR1AKR1B1ESR2PTPN1PTPN5 | |
| SCHEMBL8101456 | 0.81 | NPC1 (0.53) | FFAR1AKR1B1ESR2PTPN1PTPN5 | |
| SCHEMBL6960961 | 0.80 | ESR2 (0.54) | FFAR1AKR1B1ESR2PTPN1PTPN5 | |
| SCHEMBL6957583 | 0.79 | ESR2 (0.56) | FFAR1AKR1B1ESR2PTPN1PTPN5 | |
| SCHEMBL6959613 | 0.78 | ESR2 (0.51) | FFAR1AKR1B1ESR2PTPN1NPC1 | |
| SCHEMBL6961627 | 0.78 | ESR2 (0.51) | FFAR1AKR1B1ESR2PTPN1PTPN5 | |
| SCHEMBL7733929 | 0.76 | MAPT (0.66) | NPC1RAB9AALDH1A1HPGDUSP2 | |
| SCHEMBL3372818 | 0.76 | MAPT (0.62) | RAB9AALDH1A1HPGDMAPTCYP1A2 | |
| SCHEMBL30763519 | 0.76 | ELANE (0.51) | FFAR1AKR1B1ESR2PTPN1PTPN5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6117885-A | Biphenyl-substituted quinoline derivatives | E. R. SQUIBB & SONS, INC. (US) | 2000-09-12 | — | — | US | disclosed |
| EP-0556060-A1 | Biphenyl-substituted quinoline and naphthyridines derivatives as angiotensine II antagonists | E.R. SQUIBB & SONS, INC. (US) | 1993-08-18 | — | — | EP | disclosed |