Phthalimide

Phthalimide

SCHEMBL8099577

C=CCc1cccs1.O=C1NC(=O)c2ccccc21

nearest known ligand 0.47

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
GSK3B P49841 1/20 0.47
CASP3 P42574 1/20 0.42
CASP2 P42575 1/20 0.42
CASP7 P55210 1/20 0.42
CASP6 P55212 1/20 0.42
CASP8 Q14790 1/20 0.42
HSD17B10 Q99714 4/20 0.40
ALDH1A1 P00352 7/20 0.37
HPGD P15428 6/20 0.37
MAPT P10636 3/20 0.37
SMN1; SMN2 Q16637 2/20 0.37
HTT P42858 2/20 0.37
ALOX12 P18054 1/20 0.37
TDP1 Q9NUW8 1/20 0.37
KMT2A Q03164 3/20 0.36
MEN1 O00255 2/20 0.36
LMNA P02545 3/20 0.36
MAPK1 P28482 2/20 0.36
TP53 P04637 1/20 0.36
POLB P06746 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29660 0.81
SCHEMBL9628677 0.79
Hydrochloric Acid SCHEMBL27656714 0.79
Ammonia Solution, Strong SCHEMBL1585279 0.79
SCHEMBL8524441 0.79
Methane SCHEMBL21683042 0.79
Ethyne SCHEMBL28753719 0.77 TAAR1 (0.43) HSD17B10ALDH1A1HPGDSMN1; SMN2HTT
Piperazine SCHEMBL28840953 0.75 TAAR1 (0.38) HSD17B10ALDH1A1HPGDMAPTHTT
SCHEMBL14361741 0.75 TAAR1 (0.38) HSD17B10ALDH1A1HPGDSMN1; SMN2TDP1
Glycolic Acid SCHEMBL11501012 0.72 CYP2C19 (0.47) HSD17B10ALDH1A1HPGDSMN1; SMN2TDP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-114315689-B Disulfanylphthalimide compound, preparation method and application thereof 四川大学 2023-04-07 CN claimed
CN-115724786-A Amide alkane dithiophthalimide compound, preparation method and application thereof 四川大学 2023-03-03 CN claimed
CN-114315689-A Disulfanylphthalimide compound, preparation method and application thereof 四川大学 2022-04-12 CN claimed
CN-114315689-B Disulfanylphthalimide compound, preparation method and application thereof 四川大学 2023-04-07 CN disclosed
CN-115724786-A Amide alkane dithiophthalimide compound, preparation method and application thereof 四川大学 2023-03-03 CN disclosed
CN-114315689-A Disulfanylphthalimide compound, preparation method and application thereof 四川大学 2022-04-12 CN disclosed
US-6166003-A Heterocyclic compounds for cancer chemoprevention LKT LABORATORIES, INC. (US) 2000-12-26 US disclosed
WO-2000049013-A1 ISOTHIO CYANATO ALKYLTHIOPHENES AS CANCER CHEMOPROTECTIVE AGENTS LKT LABORATORIES, INC. (US) 2000-08-24 WO disclosed