⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17153412 | 0.89 | — | — | |
| SCHEMBL1282355 | 0.79 | FFAR3 (0.31) | — | |
| SCHEMBL13268560 | 0.77 | — | — | |
| SCHEMBL3410632 | 0.74 | FFAR3 (0.31) | — | |
| Hydrochloric Acid SCHEMBL26986852 | 0.74 | — | — | |
| SCHEMBL9756179 | 0.69 | FFAR3 (0.35) | — | |
| SCHEMBL159516 | 0.65 | — | — | |
| SCHEMBL23870324 | 0.64 | ALDH1A1 (0.34) | — | |
| SCHEMBL9015584 | 0.59 | — | — | |
| SCHEMBL113962 | 0.58 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 21 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118834204-A | Pharmaceutical process and intermediates | 阿斯利康(瑞典)有限公司 | 2024-10-25 | — | — | CN | disclosed |
| CN-113195728-B | Pharmaceutical process and intermediates | 阿斯利康(瑞典)有限公司 | 2024-07-16 | — | — | CN | disclosed |
| EP-3356344-B1 | ISOINDOLINONE INHIBITORS OF THE MDM2-P53 INTERACTION HAVING ANTICANCER ACTIVITY | ASTEX THERAPEUTICS LTD (GB) | 2022-11-16 | — | — | EP | disclosed |
| CN-108473464-B | Isoindolinone inhibitors of MDM2-P53 interaction with anti-cancer activity | 阿斯泰克斯治疗有限公司 | 2022-08-23 | — | — | CN | disclosed |
| US-20220106287-A1 | ISOINDOLINONE INHIBITORS OF THE MDM2-P53 INTERACTION HAVING ANTICANCER ACTIVITY | ASTEX THERAPEUTICS LIMITED (GB) | 2022-04-07 | — | — | US | disclosed |
| US-11261171-B1 | Isoindolinone inhibitors of the MDM2-P53 interaction having anticancer activity | ASTEX THERAPEUTICS LIMITED (GB) | 2022-03-01 | — | — | US | disclosed |
| US-20220056027-A1 | PHARMACEUTICAL PROCESS AND INTERMEDIATES | ASTRAZENECA AB (SE) | 2022-02-24 | — | — | US | disclosed |
| EP-3899004-A2 | PHARMACEUTICAL PROCESS AND INTERMEDIATES | Astrazeneca AB (SE) | 2021-10-27 | — | — | EP | disclosed |
| CN-113195728-A | Pharmaceutical process and intermediates | 阿斯利康(瑞典)有限公司 | 2021-07-30 | — | — | CN | disclosed |
| WO-2020127208-A2 | PHARMACEUTICAL PROCESS AND INTERMEDIATES | ASTRAZENECA AB (SE) | 2020-06-25 | — | — | WO | disclosed |
| EP-3356344-A1 | ISOINDOLINONE INHIBITORS OF THE MDM2-P53 INTERACTION HAVING ANTICANCER ACTIVITY | Astex Therapeutics Ltd (GB) | 2018-08-08 | — | — | EP | disclosed |
| EP-0775125-B1 | SACCHARINE DERIVATIVES AND THEIR USE AS HERBICIDES | BASF AG (DE) | 2000-12-27 | — | — | EP | disclosed |
| EP-0810998-B1 | PHENYL DIKETONE DERIVATIVES AS HERBICIDES | BASF AG (DE) | 2000-04-26 | — | — | EP | disclosed |
| US-5846906-A | Herbicidally active phenyldiketone compounds | BASF AKTIENGESELLSCHAFT (DE) | 1998-12-08 | — | — | US | disclosed |
| US-5716905-A | HERBICIDES | BASF AKTIENGESELLSCHAFT (DE) | 1998-02-10 | — | — | US | disclosed |
| EP-0810998-A1 | PHENYL DIKETONE DERIVATIVES | BASF AKTIENGESELLSCHAFT (DE) | 1997-12-10 | — | — | EP | disclosed |
| WO-1997019071-A1 | 2-CYANO-1,3-DIONE DERIVATIVES, THE PRODUCTION OF SAME AND THEIR USE AS HERBICIDES | BASF AKTIENGESELLSCHAFT (DE) | 1997-05-29 | — | — | WO | disclosed |
| EP-0775125-A1 | SACCHARINE DERIVATIVES AND THEIR USE AS HERBICIDES | BASF AKTIENGESELLSCHAFT (DE) | 1997-05-28 | — | — | EP | disclosed |
| WO-1996026193-A1 | PHENYL DIKETONE DERIVATIVES | BASF AKTIENGESELLSCHAFT (DE) | 1996-08-29 | — | — | WO | disclosed |
| WO-1996005183-A1 | SACCHARINE DERIVATIVES AND THEIR USE AS HERBICIDES | BASF AKTIENGESELLSCHAFT (DE) | 1996-02-22 | — | — | WO | disclosed |