Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.64 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.64 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.56 |
| ▸ | TP53 | P04637 | 2/20 | 0.56 |
| ▸ | RAD51 | Q06609 | 5/20 | 0.55 |
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | MAPT | P10636 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 4/20 | 0.47 |
| ▸ | RAB9A | P51151 | 4/20 | 0.47 |
| ▸ | HPGD | P15428 | 2/20 | 0.47 |
| ▸ | POLB | P06746 | 2/20 | 0.44 |
| ▸ | GAA | P10253 | 2/20 | 0.44 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.44 |
| ▸ | PKM | P14618 | 2/20 | 0.43 |
| ▸ | USP7 | Q93009 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8100226 | 0.90 | KDM4E (0.59) | KDM4EALDH1A1SMN1; SMN2TP53RAD51 | |
| SCHEMBL7925160 | 0.90 | KDM4E (0.59) | KDM4EALDH1A1SMN1; SMN2TP53RAD51 | |
| SCHEMBL1661610 | 0.89 | KDM4E (0.62) | KDM4EALDH1A1SMN1; SMN2TP53RAD51 | |
| SCHEMBL8101681 | 0.87 | KDM4E (0.61) | KDM4EALDH1A1SMN1; SMN2TP53MAPT | |
| SCHEMBL1660011 | 0.87 | RAD51 (0.51) | KDM4EALDH1A1SMN1; SMN2TP53RAD51 | |
| SCHEMBL8101672 | 0.85 | KDM4E (0.65) | KDM4EALDH1A1SMN1; SMN2RAD51LMNA | |
| SCHEMBL8108176 | 0.84 | KDM4E (0.56) | KDM4EALDH1A1SMN1; SMN2TP53RAD51 | |
| SCHEMBL1658662 | 0.84 | RAD51 (0.49) | KDM4EALDH1A1SMN1; SMN2TP53RAD51 | |
| SCHEMBL1660062 | 0.81 | RAD51 (0.48) | KDM4EALDH1A1SMN1; SMN2TP53RAD51 | |
| SCHEMBL8102024 | 0.80 | ALDH1A1 (0.55) | KDM4EALDH1A1SMN1; SMN2LMNAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6071930-A | FOR INHIBITION OF MITOSIS OR TUMOR GROWTH | THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL (US) | 2000-06-06 | — | — | US | disclosed |
| US-5994367-A | PREVENT CELL MITOSIS; ANTICARCINOGENIC AGENTS | THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL (US) | 1999-11-30 | — | — | US | disclosed |