Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSK | P43235 | 19/20 | 0.57 |
| ▸ | CTSS | P25774 | 11/20 | 0.55 |
| ▸ | CTSB | P07858 | 10/20 | 0.55 |
| ▸ | KCNH2 | Q12809 | 5/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8111806 | 0.89 | CTSK (0.57) | CTSKCTSSCTSBKCNH2 | |
| SCHEMBL8114117 | 0.88 | CTSK (0.60) | CTSKCTSSCTSBKCNH2 | |
| SCHEMBL8111751 | 0.86 | CTSK (0.57) | CTSKCTSSCTSBKCNH2 | |
| SCHEMBL8109815 | 0.86 | CTSK (0.69) | CTSKCTSSCTSBKCNH2 | |
| SCHEMBL8105988 | 0.86 | CTSK (0.69) | CTSKCTSSCTSBKCNH2 | |
| SCHEMBL8100400 | 0.84 | CTSK (0.62) | CTSKCTSSCTSBKCNH2 | |
| SCHEMBL8110155 | 0.81 | CTSK (0.58) | CTSKCTSSCTSBKCNH2 | |
| SCHEMBL8111646 | 0.80 | CTSK (0.58) | CTSKCTSSCTSBKCNH2 | |
| SCHEMBL8105816 | 0.79 | CTSK (0.62) | CTSKCTSSCTSBKCNH2 | |
| SCHEMBL8096763 | 0.77 | CTSK (0.62) | CTSKCTSSCTSBKCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009001127-A1 | CYANOCYCLOPROPYLCARBOXAMIDES AS CATHEPSIN INHIBITORS | ASTRAZENECA AB (SE) | 2008-12-31 | — | — | WO | disclosed |