Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 11/20 | 0.58 |
| ▸ | PTGS1 | P23219 | 5/20 | 0.58 |
| ▸ | CNR1 | P21554 | 4/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | APAF1 | O14727 | 1/20 | 0.39 |
| ▸ | USP2 | O75604 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | PPARG | P37231 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | NCOA2 | Q15596 | 1/20 | 0.39 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.38 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.38 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.38 |
| ▸ | IKBKB | O14920 | 1/20 | 0.37 |
| ▸ | CHUK | O15111 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8776763 | 0.92 | PTGS2 (0.48) | PTGS2PTGS1CNR1SMN1; SMN2TP53 | |
| SCHEMBL8086011 | 0.91 | PTGS2 (0.59) | PTGS2PTGS1CNR1KDM4EALDH1A1 | |
| SCHEMBL8094773 | 0.90 | PTGS2 (0.58) | PTGS2PTGS1CNR1 | |
| SCHEMBL8093419 | 0.90 | PTGS2 (0.72) | PTGS2PTGS1CNR1 | |
| SCHEMBL8086268 | 0.89 | PTGS2 (0.57) | PTGS2PTGS1CNR1MAPK8MAPK9 | |
| SCHEMBL8086370 | 0.87 | PTGS2 (0.68) | PTGS2PTGS1CNR1 | |
| SCHEMBL8087151 | 0.86 | PTGS2 (0.67) | PTGS2PTGS1CNR1 | |
| SCHEMBL8095038 | 0.86 | PTGS2 (0.56) | PTGS2PTGS1CNR1SMN1; SMN2KDM4E | |
| SCHEMBL8086716 | 0.85 | PTGS2 (0.53) | PTGS2PTGS1CNR1 | |
| SCHEMBL8085692 | 0.85 | KDM4E (0.42) | PTGS2PTGS1CNR1SMN1; SMN2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0808304-B1 | 2,3-SUBSTITUTED PYRIDINES FOR THE TREATMENT OF INFLAMMATION | SEARLE & CO (US) | 2000-12-27 | — | — | EP | disclosed |
| US-5916905-A | ANTIARTHRITIC AGENTS; ANALGESICS; ANTIPYRETICS | G. D. SEARLE & CO. (US) | 1999-06-29 | — | — | US | disclosed |
| US-5686470-A | 2, 3-substituted pyridines for the treatment of inflammation | WEIER RICHARD M (US) | 1997-11-11 | — | — | US | disclosed |