Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 13/20 | 0.56 |
| ▸ | PTGS1 | P23219 | 6/20 | 0.56 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.45 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.45 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.45 |
| ▸ | CNR1 | P21554 | 5/20 | 0.44 |
| ▸ | CNR2 | P34972 | 1/20 | 0.43 |
| ▸ | KDM1A | O60341 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8101755 | 0.99 | PTGS2 (0.58) | PTGS2PTGS1MAPK8MAPK9MAPK10 | |
| SCHEMBL8093970 | 0.98 | PTGS2 (0.54) | PTGS2PTGS1MAPK8MAPK9MAPK10 | |
| SCHEMBL8099978 | 0.96 | PTGS2 (0.52) | PTGS2PTGS1CNR1CNR2KDM1A | |
| SCHEMBL8101167 | 0.91 | PTGS2 (0.45) | PTGS2PTGS1CNR1CNR2KDM1A | |
| SCHEMBL8094910 | 0.90 | PTGS2 (0.46) | PTGS2PTGS1CNR1CNR2KDM1A | |
| SCHEMBL8098730 | 0.89 | CNR1 (0.44) | PTGS2PTGS1CNR1CNR2KDM1A | |
| SCHEMBL8099746 | 0.87 | CNR1 (0.46) | PTGS2PTGS1CNR1CNR2KDM1A | |
| SCHEMBL8100740 | 0.86 | PTGS2 (0.58) | PTGS2PTGS1MAPK8MAPK9MAPK10 | |
| SCHEMBL8092731 | 0.84 | PTGS2 (0.64) | PTGS2PTGS1CNR1 | |
| SCHEMBL8095103 | 0.84 | CNR1 (0.61) | PTGS2PTGS1CNR1CNR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0808304-B1 | 2,3-SUBSTITUTED PYRIDINES FOR THE TREATMENT OF INFLAMMATION | SEARLE & CO (US) | 2000-12-27 | — | — | EP | disclosed |
| US-5916905-A | ANTIARTHRITIC AGENTS; ANALGESICS; ANTIPYRETICS | G. D. SEARLE & CO. (US) | 1999-06-29 | — | — | US | disclosed |
| EP-0808304-A1 | 2,3-SUBSTITUTED PYRIDINES FOR THE TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 1997-11-26 | — | — | EP | disclosed |
| US-5686470-A | 2, 3-substituted pyridines for the treatment of inflammation | WEIER RICHARD M (US) | 1997-11-11 | — | — | US | disclosed |
| WO-1996024584-A1 | 2,3-SUBSTITUTED PYRIDINES FOR THE TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 1996-08-15 | — | — | WO | disclosed |