Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CMA1 | P23946 | 18/20 | 0.75 |
| ▸ | CTSG | P08311 | 3/20 | 0.62 |
| ▸ | HTR1D | P28221 | 1/20 | 0.36 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8120831 | 0.90 | CMA1 (0.62) | CMA1CTSGLMNASMN1; SMN2CYP1A2 | |
| SCHEMBL2310839 | 0.86 | CMA1 (1.00) | CMA1CTSGHTR1DOPRK1LMNA | |
| SCHEMBL8123576 | 0.83 | CMA1 (0.69) | CMA1CTSGHTR1DOPRK1LMNA | |
| SCHEMBL2311594 | 0.82 | CMA1 (0.70) | CMA1CTSGHTR1DOPRK1LMNA | |
| SCHEMBL2309515 | 0.81 | CMA1 (0.68) | CMA1CTSGHTR1DOPRK1LMNA | |
| SCHEMBL8105375 | 0.81 | CMA1 (0.62) | CMA1CTSGLMNASMN1; SMN2CYP1A2 | |
| SCHEMBL2312875 | 0.81 | CMA1 (0.67) | CMA1CTSGHTR1DOPRK1LMNA | |
| SCHEMBL8113397 | 0.81 | CMA1 (0.67) | CMA1CTSGHTR1DOPRK1LMNA | |
| SCHEMBL2311433 | 0.80 | CMA1 (0.66) | CMA1CTSGLMNASMN1; SMN2 | |
| SCHEMBL2312204 | 0.80 | CMA1 (0.66) | CMA1CTSGHTR1DOPRK1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2152674-B1 | BENZIMIDAZOLONE CHYMASE INHIBITORS | BOEHRINGER INGELHEIM INT (DE) | 2011-08-03 | — | — | EP | disclosed |
| WO-2008147697-A1 | BENZIMIDAZOLONE CHYMASE INHIBITORS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2008-12-04 | — | — | WO | disclosed |