Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.45 |
| ▸ | MTNR1A | P48039 | 4/20 | 0.43 |
| ▸ | MTNR1B | P49286 | 4/20 | 0.43 |
| ▸ | FAAH | O00519 | 1/20 | 0.42 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.41 |
| ▸ | MAOB | P27338 | 1/20 | 0.40 |
| ▸ | CNR1 | P21554 | 1/20 | 0.39 |
| ▸ | CNR2 | P34972 | 1/20 | 0.39 |
| ▸ | HTR2A | P28223 | 1/20 | 0.39 |
| ▸ | HTR2C | P28335 | 1/20 | 0.39 |
| ▸ | HTR2B | P41595 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8101946 | 1.00 | SIRT2 (0.45) | SIRT2MTNR1AMTNR1BFAAHSLC2A1 | |
| SCHEMBL8102421 | 0.88 | MTNR1A (0.45) | SIRT2MTNR1AMTNR1BCNR1CNR2 | |
| SCHEMBL8102424 | 0.88 | MTNR1A (0.45) | SIRT2MTNR1AMTNR1BCNR1CNR2 | |
| SCHEMBL8096171 | 0.88 | MTNR1A (0.55) | MTNR1AMTNR1B | |
| SCHEMBL8096172 | 0.88 | MTNR1A (0.55) | MTNR1AMTNR1B | |
| SCHEMBL8097656 | 0.85 | SIRT2 (0.46) | SIRT2MTNR1AMTNR1BCNR2ALDH1A1 | |
| SCHEMBL8097653 | 0.85 | SIRT2 (0.46) | SIRT2MTNR1AMTNR1BCNR2ALDH1A1 | |
| SCHEMBL8095712 | 0.85 | HTR2A (0.53) | MTNR1AMTNR1BHTR2AHTR2CHTR2B | |
| SCHEMBL8095710 | 0.85 | HTR2A (0.53) | MTNR1AMTNR1BHTR2AHTR2CHTR2B | |
| SCHEMBL8104382 | 0.83 | MTNR1A (0.58) | MTNR1AMTNR1BCNR1CNR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0747346-B1 | N-acyl-2 aryl cyclopropylmethylamine derivatives as melatonergics | BRISTOL MYERS SQUIBB CO (US) | 2000-02-16 | — | — | EP | disclosed |
| EP-0747346-A2 | N-acyl-2 aryl cyclopropylmethylamine derivatives as melatonergics | BRISTOL-MYERS SQUIBB COMPANY (US) | 1996-12-11 | — | — | EP | disclosed |