Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAD51 | Q06609 | 5/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.56 |
| ▸ | NPC1 | O15118 | 4/20 | 0.56 |
| ▸ | RAB9A | P51151 | 4/20 | 0.56 |
| ▸ | MEN1 | O00255 | 2/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.56 |
| ▸ | PAX8 | Q06710 | 2/20 | 0.56 |
| ▸ | MITF | O75030 | 1/20 | 0.56 |
| ▸ | KDM5A | P29375 | 1/20 | 0.56 |
| ▸ | KDM5C | P41229 | 1/20 | 0.56 |
| ▸ | HPGD | P15428 | 2/20 | 0.51 |
| ▸ | TP53 | P04637 | 3/20 | 0.49 |
| ▸ | MAPT | P10636 | 2/20 | 0.49 |
| ▸ | LMNA | P02545 | 2/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.49 |
| ▸ | APP | P05067 | 1/20 | 0.46 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.46 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8092460 | 0.91 | GRIN1 (0.55) | RAD51KDM4EALDH1A1SMN1; SMN2NPC1 | |
| SCHEMBL8099805 | 0.91 | NPC1 (0.58) | RAD51KDM4EALDH1A1SMN1; SMN2NPC1 | |
| SCHEMBL1660663 | 0.91 | NPC1 (0.56) | RAD51KDM4EALDH1A1SMN1; SMN2NPC1 | |
| SCHEMBL32687974 | 0.89 | KDM4E (0.54) | RAD51KDM4EALDH1A1SMN1; SMN2NPC1 | |
| SCHEMBL8092481 | 0.89 | ALDH1A3 (0.52) | RAD51KDM4EALDH1A1SMN1; SMN2NPC1 | |
| SCHEMBL32688356 | 0.87 | ALDH1A3 (0.47) | RAD51KDM4EALDH1A1SMN1; SMN2NPC1 | |
| SCHEMBL8099857 | 0.86 | NR1H4 (0.50) | RAD51KDM4EALDH1A1SMN1; SMN2NPC1 | |
| SCHEMBL8099803 | 0.85 | NPC1 (0.51) | RAD51KDM4EALDH1A1SMN1; SMN2NPC1 | |
| SCHEMBL30637493 | 0.83 | KDM4E (0.43) | RAD51KDM4EALDH1A1SMN1; SMN2NPC1 | |
| SCHEMBL32688108 | 0.83 | GAA (0.53) | KDM4ESMN1; SMN2LMNACYP2C19GRIN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6071930-A | FOR INHIBITION OF MITOSIS OR TUMOR GROWTH | THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL (US) | 2000-06-06 | — | — | US | disclosed |
| US-5994367-A | PREVENT CELL MITOSIS; ANTICARCINOGENIC AGENTS | THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL (US) | 1999-11-30 | — | — | US | disclosed |