Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.47 |
| ▸ | SLC6A4 | P31645 | 4/20 | 0.46 |
| ▸ | SLC6A2 | P23975 | 3/20 | 0.46 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 2/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | DHODH | Q02127 | 1/20 | 0.39 |
| ▸ | PLIN1 | O60240 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | PLIN5 | Q00G26 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28355498 | 0.85 | TSHR (0.55) | TSHRMEN1KMT2AMAPTALDH1A1 | |
| SCHEMBL8102937 | 0.84 | TSHR (0.54) | TSHRSLC6A4SLC6A2SLC6A3MEN1 | |
| SCHEMBL4907497 | 0.84 | TSHR (0.65) | TSHRSLC6A4SLC6A2SLC6A3MEN1 | |
| SCHEMBL3307119 | 0.84 | SLC6A2 (0.48) | TSHRSLC6A4SLC6A2SLC6A3MEN1 | |
| SCHEMBL27799475 | 0.81 | TSHR (0.50) | TSHRMEN1KMT2AMAPTALDH1A1 | |
| SCHEMBL8101670 | 0.81 | TSHR (0.50) | TSHRMEN1KMT2AMAPTALDH1A1 | |
| SCHEMBL5597833 | 0.81 | TSHR (0.50) | TSHRMEN1KMT2AMAPTALDH1A1 | |
| SCHEMBL1190027 | 0.79 | TSHR (0.49) | TSHRMEN1KMT2AMAPTALDH1A1 | |
| SCHEMBL3965550 | 0.78 | SLC6A2 (0.51) | TSHRSLC6A4SLC6A2SLC6A3KMT2A | |
| SCHEMBL27489174 | 0.78 | TSHR (0.47) | TSHRMEN1KMT2AMAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6124493-A | Process for the preparation of o-chloromethyl-phenylglyoxylic acid derivatives | NOVARTIS FINANCE CORPORATION (US) | 2000-09-26 | — | — | US | disclosed |
| EP-0782982-B1 | Process for the preparation of o-chloro-methyl-phenylglyoxylic acid derivatives | NOVARTIS AG (CH) | 2000-05-17 | — | — | EP | disclosed |
| US-5756811-A | Process for the preparation of o-chloromethyl-phenylglyoxylic acid derivatives | NOVARTIS CORPORATION (US) | 1998-05-26 | — | — | US | disclosed |
| EP-0782982-A1 | Process for the preparation of o-chloro-methyl-phenylglyoxylic acid derivatives | Novartis AG (CH) | 1997-07-09 | — | — | EP | disclosed |