Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FDFT1 | P37268 | 8/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | LPAR1 | Q92633 | 4/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8561726 | 0.91 | FDFT1 (0.47) | FDFT1ALDH1A1MAPTLPAR1MEN1 | |
| SCHEMBL8561718 | 0.91 | FDFT1 (0.47) | FDFT1ALDH1A1MAPTLPAR1MEN1 | |
| SCHEMBL8110836 | 0.91 | FDFT1 (0.46) | FDFT1LPAR1 | |
| SCHEMBL4682160 | 0.90 | FDFT1 (0.45) | FDFT1ALDH1A1MAPTLPAR1MEN1 | |
| SCHEMBL4682165 | 0.90 | FDFT1 (0.45) | FDFT1ALDH1A1MAPTLPAR1MEN1 | |
| SCHEMBL4287472 | 0.88 | FDFT1 (0.42) | FDFT1ALDH1A1SIGMAR1 | |
| SCHEMBL8560596 | 0.81 | LPAR1 (0.47) | FDFT1ALDH1A1MAPTLPAR1MEN1 | |
| SCHEMBL8567301 | 0.81 | LPAR1 (0.47) | FDFT1ALDH1A1MAPTLPAR1MEN1 | |
| SCHEMBL8566775 | 0.81 | LPAR1 (0.47) | FDFT1ALDH1A1MAPTLPAR1MEN1 | |
| SCHEMBL8116528 | 0.81 | ALDH1A1 (0.43) | FDFT1ALDH1A1MAPTMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0645378-B1 | Condensed seven- or eight-membered heterocyclic compounds useful as squalene synthetase inhibitors | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 2000-08-23 | — | — | EP | disclosed |
| US-5698691-A | ANTICHOLESTEROL AGENT; SYNTHETASE INHIBITOR; FUNGICIDE | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1997-12-16 | — | — | US | disclosed |
| EP-0645378-A1 | Condensed seven- or eight-membered heterocyclic compounds useful as squalene synthetase inhibitors | Takeda Chemical Industries, Ltd. (JP) | 1995-03-29 | — | — | EP | disclosed |