Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 2/20 | 0.49 |
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 4/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | GFER | P55789 | 1/20 | 0.41 |
| ▸ | FKBP1A | P62942 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8551142 | 0.88 | HPGD (0.47) | HPGDALDH1A1POLBEPHX2 | |
| SCHEMBL8440276 | 0.87 | TRPV1 (0.50) | HPGDTRPV1ALDH1A1KMT2ALMNA | |
| SCHEMBL27495124 | 0.87 | TRPV1 (0.50) | HPGDTRPV1ALDH1A1KMT2ALMNA | |
| SCHEMBL27476952 | 0.87 | TRPV1 (0.50) | HPGDTRPV1ALDH1A1KMT2ALMNA | |
| SCHEMBL8440280 | 0.87 | TRPV1 (0.50) | HPGDTRPV1ALDH1A1KMT2ALMNA | |
| SCHEMBL8441268 | 0.87 | TRPV1 (0.50) | HPGDTRPV1ALDH1A1KMT2ALMNA | |
| SCHEMBL8102640 | 0.86 | TRPV1 (0.51) | HPGDTRPV1ALDH1A1KMT2ALMNA | |
| SCHEMBL8442701 | 0.86 | TRPV1 (0.48) | HPGDTRPV1ALDH1A1KMT2ALMNA | |
| SCHEMBL8104145 | 0.83 | HPGD (0.40) | HPGDALDH1A1LMNATSHRPOLB | |
| SCHEMBL8441910 | 0.82 | TRPV1 (0.55) | HPGDTRPV1ALDH1A1KMT2ALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0788478-A1 | AZETIDINONE DERIVATIVES FOR THE TREATMENT OF ATHEROSCLEROSIS | SMITHKLINE BEECHAM PLC (GB) | 1997-08-13 | — | — | EP | claimed |
| WO-1996013484-A1 | AZETIDINONE DERIVATIVES FOR THE TREATMENT OF ATHEROSCLEROSIS | SMITHKLINE BEECHAM PLC (GB) | 1996-05-09 | — | — | WO | claimed |
| US-6071899-A | Azetidinone derivatives for the treatment of atherosclerosis | SMITHKLINE BEECHAM P.L.C. (GB) | 2000-06-06 | — | — | US | disclosed |