Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AA1 | P07900 | 4/20 | 0.57 |
| ▸ | HSP90AB1 | P08238 | 4/20 | 0.57 |
| ▸ | TDP2 | O95551 | 1/20 | 0.57 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.57 |
| ▸ | HKDC1 | Q2TB90 | 1/20 | 0.57 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.57 |
| ▸ | SOAT1 | P35610 | 2/20 | 0.56 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.53 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.51 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.47 |
| ▸ | FGFR2 | P21802 | 2/20 | 0.47 |
| ▸ | FGFR4 | P22455 | 2/20 | 0.47 |
| ▸ | FGFR3 | P22607 | 2/20 | 0.47 |
| ▸ | SRC | P12931 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8102319 | 0.92 | TDP2 (0.68) | HSP90AA1HSP90AB1TDP2PAX8HKDC1 | |
| SCHEMBL8102104 | 0.90 | TDP2 (0.52) | HSP90AA1HSP90AB1TDP2PAX8HKDC1 | |
| SCHEMBL8108751 | 0.88 | TDP2 (0.56) | HSP90AA1HSP90AB1TDP2PAX8HKDC1 | |
| SCHEMBL8100343 | 0.87 | HSP90AA1 (0.61) | HSP90AA1HSP90AB1TDP2PAX8HKDC1 | |
| SCHEMBL8102479 | 0.83 | TDP2 (0.59) | TDP2PAX8HKDC1TLR9SOAT1 | |
| SCHEMBL8100892 | 0.83 | TDP2 (0.59) | TDP2PAX8HKDC1TLR9SOAT1 | |
| SCHEMBL8665336 | 0.82 | TDP2 (0.58) | TDP2PAX8HKDC1TLR9SOAT1 | |
| SCHEMBL8092553 | 0.81 | TDP2 (0.61) | HSP90AA1HSP90AB1TDP2PAX8HKDC1 | |
| SCHEMBL8092735 | 0.81 | TDP2 (0.57) | TDP2PAX8HKDC1TLR9SOAT1 | |
| SCHEMBL8093107 | 0.81 | TDP2 (0.57) | TDP2PAX8HKDC1TLR9SOAT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6013674-A | INDENONE AMIDE DERIVATIVES, USEFUL FOR FOR THE INHIBITION OF LEUKOCYTE ADHERENCE TO ENDOTHELIAL CELLS; USEFUL IN THE TREATMENT OF INFLAMMATORY DISEASES, AS ARTHRITIS, ASTHAMA, PSORIASIS, RESPIRATORY DISTRESS SYNDROME, STROKE AND ULCER | ELI LILLY AND COMPANY (US) | 2000-01-11 | — | — | US | disclosed |
| EP-0882706-A1 | Cell adhesion inhibitors | ELI LILLY AND COMPANY (US) | 1998-12-09 | — | — | EP | disclosed |