Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 4/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | HTR2A | P28223 | 2/20 | 0.33 |
| ▸ | HTR2C | P28335 | 2/20 | 0.33 |
| ▸ | HTR2B | P41595 | 2/20 | 0.33 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8921189 | 0.82 | HTT (0.40) | HPGDL3MBTL1HTT | |
| SCHEMBL8921192 | 0.82 | HTT (0.40) | HPGDL3MBTL1HTT | |
| SCHEMBL8920488 | 0.81 | SLC6A2 (0.51) | MEN1KMT2ASMN1; SMN2LMNAHTR2A | |
| SCHEMBL20436754 | 0.81 | SLC6A2 (0.51) | MEN1KMT2ASMN1; SMN2LMNAHTR2A | |
| SCHEMBL8920482 | 0.81 | SLC6A2 (0.51) | MEN1KMT2ASMN1; SMN2LMNAHTR2A | |
| SCHEMBL20341081 | 0.81 | SLC6A2 (0.51) | MEN1KMT2ASMN1; SMN2LMNAHTR2A | |
| SCHEMBL10041954 | 0.81 | SLC6A2 (0.51) | MEN1KMT2ASMN1; SMN2LMNAHTR2A | |
| SCHEMBL10041960 | 0.81 | SLC6A2 (0.51) | MEN1KMT2ASMN1; SMN2LMNAHTR2A | |
| SCHEMBL8920936 | 0.81 | HPGD (0.40) | HPGDL3MBTL1NPSR1MEN1KMT2A | |
| SCHEMBL8920925 | 0.81 | HPGD (0.40) | HPGDL3MBTL1NPSR1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0645378-B1 | Condensed seven- or eight-membered heterocyclic compounds useful as squalene synthetase inhibitors | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 2000-08-23 | — | — | EP | disclosed |
| US-5698691-A | ANTICHOLESTEROL AGENT; SYNTHETASE INHIBITOR; FUNGICIDE | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1997-12-16 | — | — | US | disclosed |
| EP-0645378-A1 | Condensed seven- or eight-membered heterocyclic compounds useful as squalene synthetase inhibitors | Takeda Chemical Industries, Ltd. (JP) | 1995-03-29 | — | — | EP | disclosed |