Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.58 |
| ▸ | MAPT | P10636 | 1/20 | 0.58 |
| ▸ | G6PD | P11413 | 1/20 | 0.58 |
| ▸ | PKM | P14618 | 1/20 | 0.58 |
| ▸ | HPGD | P15428 | 1/20 | 0.58 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.58 |
| ▸ | HKDC1 | Q2TB90 | 1/20 | 0.58 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.58 |
| ▸ | MEN1 | O00255 | 1/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.54 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.52 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.52 |
| ▸ | ADORA3 | P0DMS8 | 12/20 | 0.52 |
| ▸ | PDE2A | O00408 | 1/20 | 0.48 |
| ▸ | PDE6D | O43924 | 1/20 | 0.48 |
| ▸ | PDE8A | O60658 | 1/20 | 0.48 |
| ▸ | PDE5A | O76074 | 1/20 | 0.48 |
| ▸ | PDE9A | O76083 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4979631 | 0.82 | ADORA3 (0.48) | POLBKDM4EALDH1A1MAPTG6PD | |
| SCHEMBL8112476 | 0.80 | ADORA3 (0.46) | HPGDMEN1KMT2AADORA3PDE5A | |
| SCHEMBL14361375 | 0.79 | POLB (0.68) | POLBKDM4EALDH1A1MAPTG6PD | |
| SCHEMBL2945612 | 0.78 | MEN1 (0.60) | POLBKDM4EALDH1A1MAPTG6PD | |
| SCHEMBL8117112 | 0.76 | GRIA1 (0.56) | KDM4EALDH1A1MAPTHPGDMEN1 | |
| SCHEMBL10980575 | 0.76 | KDM4E (0.71) | POLBKDM4EALDH1A1MAPTG6PD | |
| SCHEMBL9052411 | 0.75 | POLB (0.55) | POLBKDM4EALDH1A1MAPTG6PD | |
| SCHEMBL2820434 | 0.75 | POLB (0.48) | POLBKDM4EALDH1A1MAPTG6PD | |
| SCHEMBL10782970 | 0.74 | KDM4E (0.52) | POLBKDM4EALDH1A1MAPTG6PD | |
| SCHEMBL30273097 | 0.73 | PARP1 (0.51) | POLBKDM4EALDH1A1MAPTG6PD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6124287-A | TREATING DEPRESSION | BIOMEDICA FOSCAMA INDUSTRIA CHIMICOFARMACEUTICA S.P.A. (IT) | 2000-09-26 | — | — | US | disclosed |
| EP-0865442-B1 | IMIDAZO[1,2-a]QUINOXALIN-4-AMINES ACTIVE AS ADENOSINE ANTAGONISTS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS THEREOF | FOSCAMA BIOMED CHIM FARMA (IT) | 2000-07-05 | — | — | EP | disclosed |
| EP-0865442-A1 | IMIDAZO 1,2-a]QUINOXALIN-4-AMINES ACTIVE AS ADENOSINE ANTAGONISTS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS THEREOF | Biomedica Foscama Industria Chimico-Farmaceutica S.p.A. (IT) | 1998-09-23 | — | — | EP | disclosed |
| WO-1997019079-A1 | IMIDAZO[1,2-a]QUINOXALIN-4-AMINES ACTIVE AS ADENOSINE ANTAGONISTS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS THEREOF | BIOMEDICA FOSCAMA INDUSTRIA CHIMICO-FARMACEUTICA S.P.A. (IT) | 1997-05-29 | — | — | WO | disclosed |