Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK8 | P45983 | 7/20 | 0.73 |
| ▸ | LCK | P06239 | 1/20 | 0.59 |
| ▸ | MEN1 | O00255 | 1/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.57 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.57 |
| ▸ | TOP2A | P11388 | 1/20 | 0.55 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.51 |
| ▸ | HTR3B | O95264 | 1/20 | 0.51 |
| ▸ | HTR3A | P46098 | 1/20 | 0.51 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.51 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.51 |
| ▸ | IKBKB | O14920 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | THRB | P10828 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11500648 | 0.91 | MAPK8 (0.68) | MAPK8LCKMEN1KMT2ARXFP1 | |
| SCHEMBL8118265 | 0.86 | MAPK8 (0.73) | MAPK8TOP2AHTR3EHTR3BHTR3A | |
| SCHEMBL2816993 | 0.81 | IKBKB (0.68) | MAPK8TOP2AHTR3EHTR3BHTR3A | |
| SCHEMBL17895299 | 0.81 | MAPK8 (0.69) | MAPK8MEN1KMT2ARXFP1TOP2A | |
| SCHEMBL11500427 | 0.80 | MAPK8 (0.67) | MAPK8MEN1KMT2ATOP2AHTR3E | |
| SCHEMBL14044179 | 0.79 | MAPK8 (0.48) | MAPK8LCKMEN1KMT2ARXFP1 | |
| SCHEMBL17895250 | 0.79 | MAPK8 (0.66) | MAPK8TOP2A | |
| SCHEMBL22099666 | 0.79 | MAPK8 (0.69) | MAPK8HTR3EHTR3BHTR3AHTR3D | |
| SCHEMBL8110850 | 0.79 | MAPK8 (0.64) | MAPK8TOP2AHTR3EHTR3BHTR3A | |
| SCHEMBL17895204 | 0.78 | MAPK8 (0.65) | MAPK8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6124287-A | TREATING DEPRESSION | BIOMEDICA FOSCAMA INDUSTRIA CHIMICOFARMACEUTICA S.P.A. (IT) | 2000-09-26 | — | — | US | disclosed |
| EP-0865442-B1 | IMIDAZO[1,2-a]QUINOXALIN-4-AMINES ACTIVE AS ADENOSINE ANTAGONISTS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS THEREOF | FOSCAMA BIOMED CHIM FARMA (IT) | 2000-07-05 | — | — | EP | disclosed |