Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 11/20 | 0.61 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.55 |
| ▸ | DRD2 | P14416 | 1/20 | 0.39 |
| ▸ | DRD3 | P35462 | 1/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.39 |
| ▸ | EPHX2 | P34913 | 3/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.33 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.33 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.33 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.33 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.33 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.33 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8089848 | 1.00 | SIGMAR1 (0.61) | SIGMAR1HIF1ADRD2DRD3KCNH2 | |
| SCHEMBL8103079 | 1.00 | SIGMAR1 (0.61) | SIGMAR1HIF1ADRD2DRD3KCNH2 | |
| SCHEMBL8105781 | 0.89 | SIGMAR1 (0.56) | SIGMAR1HIF1ADRD2DRD3KCNH2 | |
| SCHEMBL8089739 | 0.88 | SIGMAR1 (0.55) | SIGMAR1HIF1ADRD2DRD3KCNH2 | |
| SCHEMBL8099338 | 0.88 | SIGMAR1 (0.55) | SIGMAR1HIF1ADRD2DRD3KCNH2 | |
| SCHEMBL8103198 | 0.86 | SIGMAR1 (0.59) | SIGMAR1HIF1ADRD2DRD3KCNH2 | |
| SCHEMBL8089835 | 0.85 | SIGMAR1 (0.57) | SIGMAR1HIF1ADRD2DRD3KCNH2 | |
| SCHEMBL8089836 | 0.85 | SIGMAR1 (0.57) | SIGMAR1HIF1ADRD2DRD3KCNH2 | |
| SCHEMBL8104936 | 0.77 | SIGMAR1 (0.54) | SIGMAR1HIF1ADRD2DRD3KCNH2 | |
| SCHEMBL8089588 | 0.77 | SIGMAR1 (0.54) | SIGMAR1HIF1ADRD2DRD3KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0661271-B1 | AZEPINE DERIVATIVES, PRODUCTION THEREOF, AND USE THEREOF AS SIGMA-RECEPTOR LIGANDS | ASAHI CHEMICAL IND (JP) | 2000-04-26 | — | — | EP | claimed |
| US-5658923-A | USED IN TREATING DISEASES RELATED TO SIGMA-RECEPTOR, SUCH AS SCHIZOPHRENIA | ASAHI KASEI KOGYO KABUSHIKI KAISHA (JP) | 1997-08-19 | — | — | US | claimed |
| EP-0661271-B1 | AZEPINE DERIVATIVES, PRODUCTION THEREOF, AND USE THEREOF AS SIGMA-RECEPTOR LIGANDS | ASAHI CHEMICAL IND (JP) | 2000-04-26 | — | — | EP | disclosed |
| EP-0661271-A1 | AZEPINE DERIVATIVE, PRODUCTION THEREOF, AND USE THEREOF | Asahi Kasei Kogyo Kabushiki Kaisha (JP) | 1995-07-05 | — | — | EP | disclosed |