Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 9/20 | 0.74 |
| ▸ | MEN1 | O00255 | 8/20 | 0.74 |
| ▸ | MAPT | P10636 | 4/20 | 0.74 |
| ▸ | NPC1 | O15118 | 3/20 | 0.74 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.74 |
| ▸ | RAB9A | P51151 | 2/20 | 0.74 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.74 |
| ▸ | MYOC | Q99972 | 1/20 | 0.74 |
| ▸ | LMNA | P02545 | 2/20 | 0.55 |
| ▸ | HTT | P42858 | 2/20 | 0.55 |
| ▸ | CA12 | O43570 | 1/20 | 0.54 |
| ▸ | CA1 | P00915 | 1/20 | 0.54 |
| ▸ | CA2 | P00918 | 1/20 | 0.54 |
| ▸ | CA9 | Q16790 | 1/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.53 |
| ▸ | CRHBP | P24387 | 1/20 | 0.53 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.53 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.52 |
| ▸ | RAF1 | P04049 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4954984 | 0.92 | KMT2A (0.70) | KMT2AMEN1MAPTNPC1MAPK1 | |
| Urea SCHEMBL2156950 | 0.88 | KMT2A (0.64) | KMT2AMEN1MAPTNPC1MAPK1 | |
| SCHEMBL11004478 | 0.86 | MEN1 (1.00) | KMT2AMEN1MAPTNPC1MAPK1 | |
| SCHEMBL6939617 | 0.85 | KMT2A (0.60) | KMT2AMEN1MAPTNPC1MAPK1 | |
| SCHEMBL8105065 | 0.85 | MEN1 (0.74) | KMT2AMEN1MAPTNPC1MAPK1 | |
| SCHEMBL11832409 | 0.84 | MEN1 (0.88) | KMT2AMEN1MAPTNPC1MAPK1 | |
| SCHEMBL11027238 | 0.84 | MEN1 (0.88) | KMT2AMEN1MAPTNPC1MAPK1 | |
| SCHEMBL6940372 | 0.83 | MAPT (0.53) | KMT2AMEN1MAPTNPC1MAPK1 | |
| SCHEMBL8110865 | 0.82 | KMT2A (0.66) | KMT2AMEN1MAPTNPC1MAPK1 | |
| SCHEMBL11830737 | 0.81 | MEN1 (0.82) | KMT2AMEN1MAPTNPC1MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1042278-A1 | 1,3-DISUBSTITUTED UREAS AS ACAT INHIBITORS, AND METHOD OF PREPARING THEREOF | Slovakofarma, A.S. (SK) | 2000-10-11 | — | — | EP | disclosed |
| WO-1999032437-A1 | 1,3-DISUBSTITUTED UREAS AS ACAT INHIBITORS, AND METHOD OF PREPARING THEREOF | SLOVAKOFARMA, A.S. (SK) | 1999-07-01 | — | — | WO | disclosed |