Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 4/20 | 0.56 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.43 |
| ▸ | HTR6 | P50406 | 1/20 | 0.42 |
| ▸ | HTR2A | P28223 | 3/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.40 |
| ▸ | DRD2 | P14416 | 1/20 | 0.40 |
| ▸ | DRD3 | P35462 | 1/20 | 0.40 |
| ▸ | HTR2B | P41595 | 2/20 | 0.39 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.39 |
| ▸ | HTR2C | P28335 | 1/20 | 0.38 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.38 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.38 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL8112970 | 0.99 | HTR1A (0.55) | HTR1AENPP2HTR6HTR2ACYP3A4 | |
| SCHEMBL8117442 | 0.86 | HTR1A (0.43) | HTR1ACYP3A4KDM4CKMT2ASMN1; SMN2 | |
| SCHEMBL30839494 | 0.85 | CYP3A4 (0.48) | HTR1AHTR2ACYP3A4USP2MAPT | |
| SCHEMBL9627802 | 0.85 | CYP3A4 (0.48) | HTR1AHTR2ACYP3A4USP2MAPT | |
| SCHEMBL17702811 | 0.85 | KDM4C (0.44) | HTR1AKDM4CSLC6A4MEN1KMT2A | |
| SCHEMBL17361810 | 0.84 | KDM4C (0.58) | HTR1AENPP2KDM4C | |
| SCHEMBL9464927 | 0.83 | HTR1A (0.63) | HTR1AENPP2CYP3A4USP2MAPT | |
| SCHEMBL5175120 | 0.83 | HTR1A (0.54) | HTR1AENPP2CYP3A4USP2MAPT | |
| SCHEMBL17361600 | 0.82 | KDM4C (0.53) | HTR1AKDM4C | |
| SCHEMBL5172931 | 0.82 | HTR1A (0.56) | HTR1AENPP2CYP3A4USP2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0779288-B1 | Substituted chromanylsulfonyl(thio)ureas, process for their preparation, their use in pharmaceutical compositions and preparations containing them | HOECHST AG (DE) | 2000-03-29 | — | — | EP | disclosed |
| US-5811448-A | PHARMACEUTICALS USEFUL FOR THE TREATMENT OF CARDIAC ARRHYTHMIAS | HOECHST AKTIENGESELLSCHAFT (DE) | 1998-09-22 | — | — | US | disclosed |
| EP-0779288-A1 | Substituted chromanylsulfonyl(thio)ureas, process for their preparation, their use in pharmaceutical compositions and preparations containing them | HOECHST AKTIENGESELLSCHAFT (DE) | 1997-06-18 | — | — | EP | disclosed |
| EP-0396620-B1 | AMINOMETHYL-CHROMAN AND -THIOCHROMAN COMPOUNDS | ABBOTT LABORATORIES (US) | 1993-08-11 | — | — | EP | disclosed |
| US-5185364-A | Selectively inhibit alpha-2-adrenergic receptors | ABBOTT LABORATORIES (US) | 1993-02-09 | — | — | US | disclosed |
| US-5140039-A | Antidepressants, metabolic disorders | ABBOTT LABORATORIES (US) | 1992-08-18 | — | — | US | disclosed |
| US-5089519-A | Antidepressants; antagonists for alpha-2-adrenergic receptors | ABBOTT LABORATORIES (US) | 1992-02-18 | — | — | US | disclosed |
| EP-0396620-A4 | AMINOMETHYL-CHROMAN AND -THIOCHROMAN COMPOUNDS | — | 1991-01-23 | — | — | EP | disclosed |
| EP-0396620-A1 | AMINOMETHYL-CHROMAN AND -THIOCHROMAN COMPOUNDS. | ABBOTT LAB (US) | 1990-11-14 | — | — | EP | disclosed |
| EP-0325964-A1 | Aminomethyl-chroman and -thiochroman compounds | ABBOTT LABORATORIES (US) | 1989-08-02 | — | — | EP | disclosed |
| WO-1989006534-A1 | AMINOMETHYL-CHROMAN AND -THIOCHROMAN COMPOUNDS | ABBOTT LABORATORIES (US) | 1989-07-27 | — | — | WO | disclosed |