Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1A | Q13627 | 6/20 | 0.61 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.61 |
| ▸ | GRM5 | P41594 | 1/20 | 0.57 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.51 |
| ▸ | SLC6A7 | Q99884 | 1/20 | 0.50 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.49 |
| ▸ | SCN10A | Q9Y5Y9 | 1/20 | 0.49 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.48 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.48 |
| ▸ | XDH | P47989 | 1/20 | 0.47 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.44 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.44 |
| ▸ | SYK | P43405 | 1/20 | 0.44 |
| ▸ | GALR1 | P47211 | 1/20 | 0.43 |
| ▸ | CTSA | P10619 | 1/20 | 0.43 |
| ▸ | RXRA | P19793 | 1/20 | 0.43 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.43 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30681801 | 0.83 | GRM5 (0.49) | DYRK1ACLK4GRM5NPY5RSLC6A7 | |
| SCHEMBL17100103 | 0.81 | GRM5 (0.67) | DYRK1AGRM5NPY5RSLC6A7KCNH2 | |
| SCHEMBL1978433 | 0.80 | KCNH2 (0.48) | DYRK1AGRM5NPY5RSLC6A7KCNH2 | |
| SCHEMBL3664986 | 0.79 | CLK4 (0.57) | CLK4NPY5RKCNH2SCN10A | |
| SCHEMBL19385058 | 0.79 | CSNK2A2 (0.48) | GRM5SLC6A7XDHHDAC1HDAC6 | |
| SCHEMBL30600082 | 0.79 | DYRK1A (0.55) | DYRK1AGRM5NPY5RSLC6A7KCNH2 | |
| SCHEMBL10094730 | 0.78 | KCNH2 (0.54) | DYRK1AGRM5NPY5RSLC6A7KCNH2 | |
| SCHEMBL15730155 | 0.78 | DHODH (0.51) | DYRK1AGRM5NPY5RSLC6A7KCNH2 | |
| SCHEMBL3537603 | 0.78 | ABL1 (0.52) | SLC6A7KCNH2 | |
| SCHEMBL5840598 | 0.77 | SLC13A5 (0.51) | DYRK1AGRM5NPY5RKCNH2SCN10A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108884068-A | 1- cyano-pyrolidin derivative as DUB inhibitor | 特殊治疗有限公司 | 2018-11-23 | — | — | CN | disclosed |
| EP-1019410-A1 | SPIRO-PIPERIDINE DERIVATIVES AND THEIR USE AS TACHYKININ ANTAGONISTS | MERCK SHARP & DOHME LTD. (GB) | 2000-07-19 | — | — | EP | disclosed |
| US-6060469-A | Spiro-piperidine derivatives and their use as tachykinin antagonists | MERCK SHARP & DOHME LTD. (GB) | 2000-05-09 | — | — | US | disclosed |
| WO-1997019084-A1 | SPIRO-PIPERIDINE DERIVATIVES AND THEIR USE AS TACHYKININ ANTAGONISTS | MERCK SHARP & DOHME LIMITED (GB) | 1997-05-29 | — | — | WO | disclosed |