Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.53 |
| ▸ | FAAH | O00519 | 7/20 | 0.51 |
| ▸ | BCHE | P06276 | 2/20 | 0.50 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.50 |
| ▸ | TP53 | P04637 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
| ▸ | CRHBP | P24387 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8843875 | 0.99 | TSHR (0.54) | TSHRFAAHBCHEPDE4BTP53 | |
| SCHEMBL26066841 | 0.93 | TP53 (0.50) | TSHRFAAHBCHEPDE4BTP53 | |
| SCHEMBL18152846 | 0.93 | TSHR (0.61) | TSHRFAAHBCHEPDE4BTP53 | |
| Phosphonic Acid SCHEMBL8110931 | 0.91 | FAAH (0.52) | TSHRFAAHBCHEPDE4BTP53 | |
| SCHEMBL22219425 | 0.91 | FAAH (0.49) | TSHRFAAHBCHEPDE4BTP53 | |
| SCHEMBL27207545 | 0.89 | BCHE (0.58) | TSHRFAAHBCHEPDE4BTP53 | |
| SCHEMBL27241995 | 0.89 | BCHE (0.58) | TSHRFAAHBCHEPDE4BTP53 | |
| SCHEMBL28871867 | 0.85 | TSHR (0.52) | TSHRFAAHBCHEMEN1CYP1A2 | |
| SCHEMBL27237042 | 0.84 | FAAH (0.42) | FAAHBCHETP53 | |
| SCHEMBL8114738 | 0.84 | BCHE (0.51) | FAAHBCHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0626969-B1 | CoA-IT AND PAF INHIBITORS | SMITHKLINE BEECHAM CORP (US) | 2000-05-24 | — | — | EP | disclosed |
| US-5663053-A | COENZYME A TRANSACYLASE FOR SCREENING | SMITHKLINE BEECHAM CORPORATION (US) | 1997-09-02 | — | — | US | disclosed |
| US-5648373-A | CoA-IT and PAF inhibitors | SMITHKLINE BEECHAM CORPORATION (US) | 1997-07-15 | — | — | US | disclosed |
| EP-0626969-A4 | CoA-IT AND PAF INHIBITORS. | SMITHKLINE BEECHAM CORP (US) | 1995-04-19 | — | — | EP | disclosed |
| EP-0626969-A1 | CoA-IT AND PAF INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 1994-12-07 | — | — | EP | disclosed |
| WO-1993016674-A1 | CoA-IT AND PAF INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 1993-09-02 | — | — | WO | disclosed |