Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.66 |
| ▸ | GLA | P06280 | 1/20 | 0.66 |
| ▸ | POLB | P06746 | 1/20 | 0.66 |
| ▸ | GAA | P10253 | 1/20 | 0.66 |
| ▸ | S1PR1 | P21453 | 4/20 | 0.48 |
| ▸ | S1PR3 | Q99500 | 3/20 | 0.48 |
| ▸ | IMPDH2 | P12268 | 1/20 | 0.45 |
| ▸ | PDE3B | Q13370 | 2/20 | 0.44 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.44 |
| ▸ | KIF11 | P52732 | 3/20 | 0.42 |
| ▸ | GCGR | P47871 | 1/20 | 0.40 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.40 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.38 |
| ▸ | CCNC | P24863 | 1/20 | 0.38 |
| ▸ | CDK8 | P49336 | 1/20 | 0.38 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.37 |
| ▸ | ADH5 | P11766 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7868530 | 0.87 | GAA (0.79) | TSHRGLAPOLBGAAS1PR1 | |
| SCHEMBL29964278 | 0.87 | GAA (0.79) | TSHRGLAPOLBGAAS1PR1 | |
| SCHEMBL1011735 | 0.85 | GAA (0.76) | TSHRGLAPOLBGAAS1PR1 | |
| SCHEMBL24297388 | 0.85 | GAA (0.76) | TSHRGLAPOLBGAAS1PR1 | |
| SCHEMBL4659904 | 0.84 | TSHR (0.68) | TSHRGLAPOLBGAAPDE3B | |
| Water SCHEMBL29003781 | 0.83 | GAA (0.73) | TSHRGLAPOLBGAAS1PR1 | |
| SCHEMBL27537618 | 0.83 | GAA (0.73) | TSHRGLAPOLBGAAS1PR1 | |
| SCHEMBL1926441 | 0.81 | TSHR (0.70) | TSHRGLAPOLBGAAS1PR1 | |
| SCHEMBL109685 | 0.80 | TSHR (1.00) | TSHRGLAPOLBGAAPDE3B | |
| SCHEMBL17451259 | 0.80 | TSHR (1.00) | TSHRGLAPOLBGAAPDE3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1196680-C | Modulators of dopamine neurotransmission | CARLSSON A RESEARCH AB (SE) | 2005-04-13 | — | — | CN | disclosed |
| CN-1420870-A | Modulators of dopamine neurotransmission | CARLSSON A RESEARCH AB (SE) | 2003-05-28 | — | — | CN | disclosed |
| EP-1047691-A1 | QUINOLINEPIPERAZINE AND QUINOLINEPIPERIDINE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS COMBINED 5-HT1A, 5-HT1B AND 5-HT1D RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM PLC (GB) | 2000-11-02 | — | — | EP | disclosed |
| WO-1999031086-A1 | QUINOLINEPIPERAZINE AND QUINOLINEPIPERIDINE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS COMBINED 5-HT1A, 5-HT1B AND 5-HT1D RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM PLC (GB) | 1999-06-24 | — | — | WO | disclosed |
| WO-1998050346-A2 | ACETAMIDE AND UREA DERIVATIVES, PROCESS FOR THEIR PREPARATION AND THEIR USE IN THE TREATMENT OF CNS DISORDERS | SMITHKLINE BEECHAM PLC (GB) | 1998-11-12 | — | — | WO | disclosed |