Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 8/20 | 0.74 |
| ▸ | HTR2B | P41595 | 2/20 | 0.74 |
| ▸ | PNMT | P11086 | 6/20 | 0.61 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.61 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.61 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.61 |
| ▸ | PKM | P14618 | 1/20 | 0.55 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.53 |
| ▸ | HTR2A | P28223 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4386970 | 0.90 | HTR2C (0.84) | HTR2CHTR2BPNMTADRA2AADRA2B | |
| SCHEMBL3879315 | 0.89 | HTR2C (0.66) | HTR2CHTR2BPNMTADRA2AADRA2B | |
| SCHEMBL3876586 | 0.87 | HTR2C (0.85) | HTR2CHTR2BPNMTADRA2AADRA2B | |
| SCHEMBL4770064 | 0.85 | HTR2C (1.00) | HTR2CHTR2BKCNH2HTR2A | |
| SCHEMBL4792399 | 0.81 | HTR2C (1.00) | HTR2CHTR2BPNMTKCNH2HTR2A | |
| SCHEMBL1885004 | 0.80 | PNMT (0.71) | HTR2CHTR2BPNMTADRA2AADRA2B | |
| SCHEMBL30555216 | 0.79 | HTR2C (0.61) | HTR2CHTR2BPKMKCNH2HTR2A | |
| Hydrochloric Acid SCHEMBL1075383 | 0.78 | PNMT (0.69) | HTR2CHTR2BPNMTADRA2AADRA2B | |
| SCHEMBL7014107 | 0.78 | HTR2C (0.52) | HTR2CHTR2BPNMT | |
| SCHEMBL1487047 | 0.76 | PNMT (1.00) | HTR2CHTR2BPNMTADRA2AADRA2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0986551-A1 | SULFONAMIDE DERIVATIVES, THEIR PRODUCTION AND USE | Takeda Pharmaceutical Company Limited (JP) | 2000-03-22 | — | — | EP | disclosed |
| WO-1998054164-A1 | SULFONAMIDE DERIVATIVES, THEIR PRODUCTION AND USE | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1998-12-03 | — | — | WO | disclosed |