Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 6/20 | 0.45 |
| ▸ | PIK3CD | O00329 | 6/20 | 0.45 |
| ▸ | MTOR | P42345 | 5/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.37 |
| ▸ | MEN1 | O00255 | 4/20 | 0.37 |
| ▸ | MAPT | P10636 | 4/20 | 0.37 |
| ▸ | HPGD | P15428 | 4/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.37 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CA12 | O43570 | 1/20 | 0.34 |
| ▸ | CA1 | P00915 | 1/20 | 0.34 |
| ▸ | CA2 | P00918 | 1/20 | 0.34 |
| ▸ | CA7 | P43166 | 1/20 | 0.34 |
| ▸ | CA9 | Q16790 | 1/20 | 0.34 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11925797 | 0.86 | PIK3CA (0.49) | PIK3CAPIK3CDMTORPOLBALDH1A1 | |
| SCHEMBL8099372 | 0.84 | PIK3CA (0.48) | PIK3CAPIK3CDMTORPOLBALDH1A1 | |
| SCHEMBL8216900 | 0.83 | PIK3CA (0.50) | PIK3CAPIK3CDMTORPOLBALDH1A1 | |
| SCHEMBL1755695 | 0.83 | MAP4K4 (0.46) | PIK3CAPIK3CDMTOR | |
| SCHEMBL3066685 | 0.82 | MTOR (0.71) | PIK3CAPIK3CDMTORPOLBCYP3A4 | |
| SCHEMBL8093349 | 0.82 | PIK3CD (0.48) | PIK3CAPIK3CDMTORPOLBALDH1A1 | |
| SCHEMBL8101524 | 0.82 | MEN1 (0.54) | PIK3CAPIK3CDMTORALDH1A1MEN1 | |
| SCHEMBL8218937 | 0.82 | PIK3CD (0.53) | PIK3CAPIK3CDMTORPOLBALDH1A1 | |
| SCHEMBL8106030 | 0.81 | PIK3CA (0.47) | PIK3CAPIK3CDMTORPOLBALDH1A1 | |
| SCHEMBL8109642 | 0.81 | PIK3CA (0.49) | PIK3CAPIK3CDMTORPOLBALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009007749-A2 | TRISUBSTITUTED PYRIMIDINE DERIVATIVES FOR THE TREATMENT OF PROLIFERATIVE DISEASES | ASTRAZENECA AB (SE) | 2009-01-15 | — | — | WO | disclosed |