Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV1 | Q8NER1 | 5/20 | 0.52 |
| ▸ | HPGD | P15428 | 3/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | LMNA | P02545 | 3/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | ASAH1 | Q13510 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8104079 | 1.00 | TRPV1 (0.52) | TRPV1HPGDALDH1A1KMT2ALMNA | |
| SCHEMBL8104082 | 1.00 | TRPV1 (0.52) | TRPV1HPGDALDH1A1KMT2ALMNA | |
| SCHEMBL8441538 | 0.90 | TRPV1 (0.49) | TRPV1HPGDALDH1A1KMT2ALMNA | |
| SCHEMBL8102549 | 0.84 | NPC1 (0.54) | HPGDKMT2ALMNATSHRPOLB | |
| SCHEMBL8102557 | 0.84 | NPC1 (0.54) | HPGDKMT2ALMNATSHRPOLB | |
| SCHEMBL8102553 | 0.84 | NPC1 (0.54) | HPGDKMT2ALMNATSHRPOLB | |
| SCHEMBL8104223 | 0.82 | TRPV1 (0.50) | TRPV1HPGDALDH1A1KMT2ALMNA | |
| SCHEMBL8108459 | 0.81 | TRPV1 (0.49) | TRPV1HPGDALDH1A1KMT2ALMNA | |
| SCHEMBL8108306 | 0.81 | TRPV1 (0.49) | TRPV1HPGDALDH1A1KMT2ALMNA | |
| SCHEMBL8552359 | 0.81 | TRPV1 (0.49) | TRPV1HPGDALDH1A1KMT2ALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0788478-A1 | AZETIDINONE DERIVATIVES FOR THE TREATMENT OF ATHEROSCLEROSIS | SMITHKLINE BEECHAM PLC (GB) | 1997-08-13 | — | — | EP | claimed |
| WO-1996013484-A1 | AZETIDINONE DERIVATIVES FOR THE TREATMENT OF ATHEROSCLEROSIS | SMITHKLINE BEECHAM PLC (GB) | 1996-05-09 | — | — | WO | claimed |
| US-6071899-A | Azetidinone derivatives for the treatment of atherosclerosis | SMITHKLINE BEECHAM P.L.C. (GB) | 2000-06-06 | — | — | US | disclosed |
| EP-0788478-A1 | AZETIDINONE DERIVATIVES FOR THE TREATMENT OF ATHEROSCLEROSIS | SMITHKLINE BEECHAM PLC (GB) | 1997-08-13 | — | — | EP | disclosed |
| WO-1996013484-A1 | AZETIDINONE DERIVATIVES FOR THE TREATMENT OF ATHEROSCLEROSIS | SMITHKLINE BEECHAM PLC (GB) | 1996-05-09 | — | — | WO | disclosed |