Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC3 | O15379 | 3/20 | 0.53 |
| ▸ | HDAC4 | P56524 | 3/20 | 0.53 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.53 |
| ▸ | HDAC7 | Q8WUI4 | 3/20 | 0.53 |
| ▸ | HDAC2 | Q92769 | 3/20 | 0.53 |
| ▸ | HDAC10 | Q969S8 | 3/20 | 0.53 |
| ▸ | HDAC11 | Q96DB2 | 3/20 | 0.53 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.53 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.53 |
| ▸ | HDAC9 | Q9UKV0 | 3/20 | 0.53 |
| ▸ | HDAC5 | Q9UQL6 | 3/20 | 0.53 |
| ▸ | MAOB | P27338 | 5/20 | 0.49 |
| ▸ | EGFR | P00533 | 1/20 | 0.46 |
| ▸ | GLA | P06280 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | MAPT | P10636 | 3/20 | 0.45 |
| ▸ | NPC1 | O15118 | 3/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17447202 | 1.00 | HDAC3 (0.53) | HDAC3HDAC4HDAC1HDAC7HDAC2 | |
| SCHEMBL8118316 | 1.00 | HDAC3 (0.53) | HDAC3HDAC4HDAC1HDAC7HDAC2 | |
| SCHEMBL5574375 | 1.00 | HDAC3 (0.53) | HDAC3HDAC4HDAC1HDAC7HDAC2 | |
| SCHEMBL3804989 | 0.90 | HDAC3 (0.44) | HDAC3HDAC4HDAC1HDAC7HDAC2 | |
| SCHEMBL1006098 | 0.88 | GLA (0.55) | HDAC3HDAC4HDAC1HDAC7HDAC2 | |
| SCHEMBL126771 | 0.88 | GLA (0.55) | HDAC3HDAC4HDAC1HDAC7HDAC2 | |
| SCHEMBL6676460 | 0.83 | TDP1 (0.41) | HDAC3HDAC4HDAC1HDAC7HDAC2 | |
| SCHEMBL2099331 | 0.83 | HDAC3 (0.45) | HDAC3HDAC4HDAC1HDAC7HDAC2 | |
| Formic Acid SCHEMBL8583302 | 0.83 | KMT2A (0.51) | HDAC3HDAC4HDAC1HDAC7HDAC2 | |
| SCHEMBL12310124 | 0.83 | HDAC3 (0.46) | HDAC3HDAC4HDAC1HDAC7HDAC2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0736031-B1 | IMPROVEMENTS IN OR RELATING TO CHIRAL SYNTHESES | OXFORD ASYMMETRY INTERNATIONAL (GB) | 2000-05-03 | — | — | EP | disclosed |
| US-6037498-A | Chiral syntheses | OXFORD ASYMMETRY INTERNATIONAL PLC (GB) | 2000-03-14 | — | — | US | disclosed |
| EP-0736031-A1 | IMPROVEMENTS IN OR RELATING TO CHIRAL SYNTHESES | OXFORD ASYMMETRY LIMITED (GB) | 1996-10-09 | — | — | EP | disclosed |
| WO-1995018134-A1 | IMPROVEMENTS IN OR RELATING TO CHIRAL SYNTHESES | OXFORD ASYMMETRY LIMITED (GB) | 1995-07-06 | — | — | WO | disclosed |