SCHEMBL8104987

SCHEMBL8104987

CC(C#N)(C=Cc1ccccc1)c1ccccc1

nearest known ligand 0.43

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP2C19 P33261 1/20 0.43
TSHR P16473 2/20 0.37
ALDH1A1 P00352 1/20 0.37
MAOB P27338 1/20 0.37
CYP2D6 P10635 2/20 0.35
L3MBTL1 Q9Y468 2/20 0.35
NPC1 O15118 2/20 0.35
DRD2 P14416 1/20 0.35
DRD4 P21917 1/20 0.35
OPRM1 P35372 1/20 0.35
DRD3 P35462 1/20 0.35
EGFR P00533 1/20 0.35
CHAT P28329 2/20 0.34
KDM4E B2RXH2 2/20 0.33
CYP3A4 P08684 1/20 0.33
RELA Q04206 1/20 0.33
TRPA1 O75762 1/20 0.33
GLA P06280 1/20 0.33
TDP1 Q9NUW8 1/20 0.33
MAPK1 P28482 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8104983 1.00 CYP2C19 (0.43) CYP2C19TSHRALDH1A1MAOBCYP2D6
SCHEMBL8103108 0.80 CYP2D6 (0.39) CYP2C19TSHRALDH1A1CYP2D6DRD2
SCHEMBL28440727 0.79 CYP2C19 (0.47) CYP2C19TSHRALDH1A1MAOBCYP2D6
SCHEMBL29093795 0.79 CYP2C19 (0.47) CYP2C19TSHRALDH1A1MAOBCYP2D6
Acrylonitrile SCHEMBL11774150 0.76 CYP2C19 (0.44) CYP2C19TSHRALDH1A1MAOBL3MBTL1
SCHEMBL9165033 0.75 CYP2D6 (0.38) CYP2C19ALDH1A1CYP2D6DRD2DRD4
SCHEMBL10229439 0.75 CYP2D6 (0.38) CYP2C19ALDH1A1CYP2D6DRD2DRD4
SCHEMBL6546422 0.74 CYP2C19 (0.50) CYP2C19TSHRALDH1A1MAOBNPC1
SCHEMBL28706854 0.74 CYP2C19 (0.50) CYP2C19TSHRALDH1A1MAOBNPC1
SCHEMBL4789182 0.74 CYP2C19 (0.50) CYP2C19TSHRALDH1A1MAOBNPC1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1055653-A2 Process for the preparation of alkenyl compounds BASF AKTIENGESELLSCHAFT (DE) 2000-11-29 EP disclosed