Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 | P23975 | 10/20 | 0.48 |
| ▸ | SLC6A4 | P31645 | 7/20 | 0.48 |
| ▸ | SLC6A3 | Q01959 | 5/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.47 |
| ▸ | HTR2C | P28335 | 1/20 | 0.47 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8105020 | 1.00 | SLC6A2 (0.48) | SLC6A2SLC6A4SLC6A3CYP2D6HTR2C | |
| SCHEMBL8110533 | 1.00 | SLC6A2 (0.48) | SLC6A2SLC6A4SLC6A3CYP2D6HTR2C | |
| Hydrochloric Acid SCHEMBL8318652 | 0.98 | SLC6A2 (0.48) | SLC6A2SLC6A4SLC6A3CYP2D6HTR2C | |
| Hydrochloric Acid SCHEMBL8318649 | 0.98 | SLC6A2 (0.48) | SLC6A2SLC6A4SLC6A3CYP2D6HTR2C | |
| SCHEMBL8097325 | 0.84 | SLC22A1 (0.51) | SLC6A2SLC6A4HTR2CSIGMAR1 | |
| SCHEMBL8097321 | 0.84 | SLC22A1 (0.51) | SLC6A2SLC6A4HTR2CSIGMAR1 | |
| SCHEMBL27946788 | 0.81 | SLC6A2 (0.54) | SLC6A2SLC6A4SLC6A3CYP2D6HTR2C | |
| SCHEMBL8112638 | 0.80 | SLC6A4 (0.46) | SLC6A2SLC6A4SLC6A3CYP2D6HTR2C | |
| SCHEMBL3745740 | 0.80 | SLC6A2 (0.49) | SLC6A2SLC6A4SLC6A3CYP2D6HTR2C | |
| SCHEMBL13835677 | 0.80 | SLC6A2 (0.49) | SLC6A2SLC6A4SLC6A3CYP2D6HTR2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6124354-A | TREATMENT OF URINARY INCONTINENCE OR IRRITABLE BOWEL SYNDROME | PHARMACIA & UPJOHN AB (SE) | 2000-09-26 | — | — | US | disclosed |
| CN-1226886-A | Arylcycloalkane carboxylic acid esters, their use, pharmaceutical compositions and process for their preparation | PHARMACIA & UPJOHN AB (SE) | 1999-08-25 | — | — | CN | disclosed |
| EP-0923536-A1 | ARYLCYCLOALKANE CARBOXYLIC ESTERS, THEIR USE, PHARMACEUTICAL COMPOSITIONS AND PREPARATION | Pharmacia & Upjohn Aktiebolag (SE) | 1999-06-23 | — | — | EP | disclosed |
| WO-1998004517-A1 | ARYLCYCLOALKANE CARBOXYLIC ESTERS, THEIR USE, PHARMACEUTICAL COMPOSITIONS AND PREPARATION | PHARMACIA & UPJOHN AB (SE) | 1998-02-05 | — | — | WO | disclosed |