Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 5/20 | 0.62 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | DHFR | P00374 | 1/20 | 0.44 |
| ▸ | AGTR1 | P30556 | 4/20 | 0.43 |
| ▸ | AGTR2 | P50052 | 4/20 | 0.43 |
| ▸ | LTB4R2 | Q9NPC1 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8095962 | 0.95 | PPARG (0.56) | PPARGAGTR1AGTR2LTB4R2 | |
| SCHEMBL8104965 | 0.95 | PPARG (0.59) | PPARGAGTR1AGTR2LTB4R2 | |
| SCHEMBL8105265 | 0.92 | PPARG (0.55) | PPARGAGTR1AGTR2 | |
| SCHEMBL8096101 | 0.91 | PPARG (0.54) | PPARGAGTR1AGTR2 | |
| SCHEMBL8105656 | 0.87 | PPARG (0.47) | PPARGNPC1RAB9ASMN1; SMN2AGTR1 | |
| SCHEMBL8111149 | 0.86 | PPARG (0.49) | PPARGNPC1RAB9ASMN1; SMN2DHFR | |
| SCHEMBL8103387 | 0.86 | PPARG (0.50) | PPARGAGTR1AGTR2 | |
| SCHEMBL8103612 | 0.86 | PPARG (0.56) | PPARGNPC1RAB9ASMN1; SMN2DHFR | |
| SCHEMBL8109299 | 0.85 | PPARG (0.57) | PPARGNPC1RAB9ASMN1; SMN2DHFR | |
| SCHEMBL8105308 | 0.84 | PPARG (0.47) | PPARGNPC1RAB9ASMN1; SMN2DHFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-3098772-B2 | — | — | 2000-10-16 | — | — | JP | claimed |
| EP-0527851-A1 | 1H-SUBSTITUTED-1,2,4-TRIAZOLE COMPOUNDS FOR TREATMENT OF CARDIOVASCULAR DISORDERS | G.D. SEARLE & CO. (US) | 1993-02-24 | — | — | EP | claimed |
| WO-1991017148-A1 | 1H-SUBSTITUTED-1,2,4-TRIAZOLE COMPOUNDS FOR TREATMENT OF CARDIOVASCULAR DISORDERS | G.D. SEARLE & CO. (US) | 1991-11-14 | — | — | WO | claimed |
| US-5098920-A | Hypotensive agents and treatment of congestive heart failure | G. D. SEARLE & CO. (US) | 1992-03-24 | — | — | US | disclosed |