Predicted protein targets (top 2)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSK | P43235 | 18/20 | 0.65 |
| ▸ | CTSB | P07858 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2248488 | 0.89 | CTSK (0.82) | CTSKCTSB | |
| SCHEMBL12364536 | 0.86 | CTSK (0.59) | CTSKCTSB | |
| SCHEMBL29076287 | 0.81 | CTSK (0.52) | CTSKCTSB | |
| SCHEMBL29076290 | 0.81 | CTSK (0.52) | CTSKCTSB | |
| SCHEMBL30497445 | 0.81 | CTSK (0.52) | CTSKCTSB | |
| SCHEMBL2243809 | 0.80 | CTSK (0.78) | CTSKCTSB | |
| SCHEMBL2243179 | 0.79 | CTSK (0.76) | CTSKCTSB | |
| SCHEMBL3264277 | 0.79 | CTSK (0.76) | CTSKCTSB | |
| SCHEMBL2246364 | 0.79 | CTSK (1.00) | CTSKCTSB | |
| SCHEMBL2244439 | 0.79 | CTSK (0.78) | CTSKCTSB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2170879-B1 | 1-CYANOCYCLOPROPYL-DERIVATIVES AS CATHEPSIN K INHIBITORS | ASTRAZENECA AB (SE) | 2013-01-16 | — | — | EP | disclosed |
| WO-2009001129-A9 | 1-CYANOCYCLOPROPYL-DERIVATIVES AS CATHEPSIN K INHIBITORS | ASTRAZENECA AB (SE) | 2010-02-04 | — | — | WO | disclosed |
| WO-2009001129-A1 | 1-CYANOCYCLOPROPYL-DERIVATIVES AS CATHEPSIN K INHIBITORS | ASTRAZENECA AB (SE) | 2008-12-31 | — | — | WO | disclosed |