SCHEMBL8105728

SCHEMBL8105728

CCOC(=O)c1c([Si](C)(C)C)ccc2c1CCC(NS(=O)(=O)c1ccc(Cl)cc1)C2

nearest known ligand 0.56

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
TBXA2R P21731 9/20 0.56
HDAC8 Q9BY41 2/20 0.47
TBXAS1 P24557 7/20 0.44
POLB P06746 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9251507 0.89 TBXA2R (0.65) TBXA2RHDAC8TBXAS1POLB
SCHEMBL9247878 0.88 TBXA2R (0.58) TBXA2RHDAC8TBXAS1
SCHEMBL7776609 0.87 TBXA2R (0.59) TBXA2RHDAC8TBXAS1
SCHEMBL8119832 0.84 TBXA2R (0.49) TBXA2RHDAC8TBXAS1
SCHEMBL7771706 0.81 TBXA2R (0.61) TBXA2RHDAC8TBXAS1
SCHEMBL9253927 0.80 TBXA2R (0.65) TBXA2RHDAC8TBXAS1
SCHEMBL7777991 0.79 TBXA2R (0.53) TBXA2RHDAC8TBXAS1
SCHEMBL9251138 0.79 TBXA2R (0.54) TBXA2RHDAC8TBXAS1
SCHEMBL9015468 0.78 TBXA2R (0.70) TBXA2RHDAC8TBXAS1
SCHEMBL8115712 0.77 TBXA2R (0.52) TBXA2RHDAC8TBXAS1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6013667-A Benzenesulfonylamine compounds, process for preparing them and pharmaceutical compositions ADIR ET COMPAGNIE (FR) 2000-01-11 US disclosed
US-5472979-A Antithrombotics ADIR ET COMPAGNIE (FR) 1995-12-05 US disclosed