SCHEMBL8105743

SCHEMBL8105743

C=COC(=O)/C(C#N)=C/c1ccccc1

nearest known ligand 0.58

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MCL1 Q07820 1/20 0.58
ALDH1A1 P00352 5/20 0.51
KDM4E B2RXH2 3/20 0.49
PLIN1 O60240 1/20 0.49
LMNA P02545 1/20 0.49
PLIN5 Q00G26 1/20 0.49
ABHD5 Q8WTS1 1/20 0.49
POLB P06746 1/20 0.48
PKM P14618 1/20 0.47
KMT2A Q03164 1/20 0.47
ATM Q13315 1/20 0.47
CISD1 Q9NZ45 1/20 0.46
SLC16A3 O15427 1/20 0.46
CYP3A4 P08684 1/20 0.46
HPGD P15428 1/20 0.46
SLC16A1 P53985 1/20 0.46
GPR35 Q9HC97 1/20 0.46
EGFR P00533 1/20 0.46
MAPT P10636 1/20 0.45
RECQL P46063 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8665795 1.00 MCL1 (0.58) MCL1ALDH1A1KDM4EPLIN1LMNA
SCHEMBL21457765 0.85 MCL1 (0.60) MCL1ALDH1A1KDM4EPLIN1LMNA
SCHEMBL7153194 0.80 PTP4A3 (0.63) MCL1ALDH1A1KDM4EPLIN1LMNA
SCHEMBL7153196 0.80 PTP4A3 (0.63) MCL1ALDH1A1KDM4EPLIN1LMNA
SCHEMBL4246049 0.80 MCL1 (0.62) MCL1ALDH1A1KDM4EPLIN1LMNA
SCHEMBL15537245 0.80 MCL1 (0.67) MCL1ALDH1A1KDM4EPLIN1LMNA
SCHEMBL6927070 0.80 MCL1 (0.62) MCL1ALDH1A1KDM4EPLIN1LMNA
SCHEMBL4246045 0.80 MCL1 (0.62) MCL1ALDH1A1KDM4EPLIN1LMNA
SCHEMBL2201000 0.79 MCL1 (0.60) MCL1ALDH1A1KDM4EPLIN1LMNA
SCHEMBL19278940 0.78 MEN1 (0.44) MCL1ALDH1A1KDM4EPLIN1LMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5425122-A Drawable linear polymer rod having continuous refractive index gradient distributed from peripheral portion to central portion and having crosslinkable functional groups NIPPON PETROCHEMICALS COMPANY, LIMITED (JP) 1995-06-13 US claimed
EP-0566744-B1 REFRACTIVE INDEX DISTRIBUTION TYPE OPTICAL FIBRE AND METHOD OF MANUFACTURING SAID OPTICAL FIBRE KOIKE YASUHIRO (JP) 2000-01-05 EP disclosed
US-5767200-A OPTICAL FIBERS; CONTROLLED REFRACTIVE INDEX KOIKE YASUHIRO (JP) 1998-06-16 US disclosed
US-5763514-A OPTICAL CONDUCTORS WHICH INCLUDE OPTICAL FIBERS, WAVEGUIDES, OPTICAL INTEGRATED CIRCUITS KOIKE YASUHIRO (JP) 1998-06-09 US disclosed
EP-0548992-B1 Synthetic resin optical transmission medium and its preparation method NIPPON PETROCHEMICALS CO LTD (JP) 1997-03-12 EP disclosed
US-5541247-A FILLING CONTAINER WITH MIXED SOLUTION OF FIRST SUBSTANCE OF MONOMER OR MONOMER SOL AND SECOND SUBSTANCE WITH DIFFERENT SOLUBILITY AND REFRACTIVE INDEX; USING HEAT OR ENERGY RAYS TO POLYMERIZE FIRST SUBSTANCE; FORMING CONCENTRATION GRADIENT KOIKE YASUHIRO (JP) 1996-07-30 US disclosed
US-5425122-A Drawable linear polymer rod having continuous refractive index gradient distributed from peripheral portion to central portion and having crosslinkable functional groups NIPPON PETROCHEMICALS COMPANY, LIMITED (JP) 1995-06-13 US disclosed
EP-0566744-A1 OPTICAL RESIN MATERIAL OF REFRACTIVE INDEX DISTRIBUTION TYPE, METHOD OF MAKING SAID MATERIAL, AND OPTICAL TRANSMITTER KOIKE, Yasuhiro (JP) 1993-10-27 EP disclosed
EP-0548992-A1 Synthetic resin optical transmission medium and its preparation method NIPPON PETROCHEMICALS CO., LTD. (JP) 1993-06-30 EP disclosed
US-4292392-A ETCHABLE, DEVELOPABLE AND PERMEABLE USING AN ALKALINE AQUEOUS SOLUTION; CONTRAST FUJI PHOTO FILM CO., LTD. (JP) 1981-09-29 US disclosed
US-4083725-A CINNAMIC ACID PHOTOSENSITIVE RESIN AND A HALOGEN SUBSTITUTED BENZANTHRONE SENSITIZER MITSUBISHI CHEMICAL INDUSTRIES LTD. (JA) 1978-04-11 US disclosed
US-4063953-A POLYETHERS, POLYEPICHLOROHYDRIN, VINYL CINNAMATES MITSUBISHI CHEMICAL INDUSTRIES, LTD. (JA) 1977-12-20 US disclosed