Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.52 |
| ▸ | MEN1 | O00255 | 2/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.52 |
| ▸ | ALDH1A3 | P47895 | 2/20 | 0.46 |
| ▸ | NPC1 | O15118 | 4/20 | 0.45 |
| ▸ | RAB9A | P51151 | 4/20 | 0.45 |
| ▸ | PKM | P14618 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | CASP1 | P29466 | 1/20 | 0.43 |
| ▸ | CASP7 | P55210 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | BACE1 | P56817 | 1/20 | 0.42 |
| ▸ | BRD4 | O60885 | 1/20 | 0.42 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.42 |
| ▸ | ADORA2B | P29275 | 2/20 | 0.42 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21902775 | 0.91 | MEN1 (0.55) | ALDH1A1MEN1KMT2AALDH1A3MAPT | |
| SCHEMBL16375038 | 0.90 | KDM4E (0.49) | KDM4EALDH1A1MEN1KMT2AALDH1A3 | |
| SCHEMBL8101672 | 0.87 | KDM4E (0.65) | KDM4EALDH1A1MEN1KMT2ANPC1 | |
| SCHEMBL8101681 | 0.86 | KDM4E (0.61) | KDM4EALDH1A1MEN1KMT2AALDH1A3 | |
| SCHEMBL7925220 | 0.85 | MEN1 (0.57) | KDM4EALDH1A1MEN1KMT2AALDH1A3 | |
| SCHEMBL16213620 | 0.83 | KDM4E (0.50) | KDM4EALDH1A1MEN1KMT2ANPC1 | |
| SCHEMBL1661610 | 0.83 | KDM4E (0.62) | KDM4EALDH1A1MEN1KMT2ANPC1 | |
| SCHEMBL8099894 | 0.82 | MEN1 (0.52) | KDM4EALDH1A1MEN1KMT2AALDH1A3 | |
| SCHEMBL8102024 | 0.82 | ALDH1A1 (0.55) | KDM4EALDH1A1MEN1KMT2ANPC1 | |
| SCHEMBL1660020 | 0.82 | MEN1 (0.56) | KDM4EALDH1A1MEN1KMT2ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6071930-A | FOR INHIBITION OF MITOSIS OR TUMOR GROWTH | THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL (US) | 2000-06-06 | — | — | US | disclosed |
| US-5994367-A | PREVENT CELL MITOSIS; ANTICARCINOGENIC AGENTS | THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL (US) | 1999-11-30 | — | — | US | disclosed |