Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIA3 | P42263 | 1/20 | 0.52 |
| ▸ | GRIA4 | P48058 | 1/20 | 0.52 |
| ▸ | SLC18A3 | Q16572 | 1/20 | 0.43 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.43 |
| ▸ | HSD11B1 | P28845 | 14/20 | 0.41 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.41 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.41 |
| ▸ | TAS1R2 | Q8TE23 | 1/20 | 0.41 |
| ▸ | CNR2 | P34972 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.39 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8107156 | 0.87 | GRIA3 (0.58) | GRIA3GRIA4HSD11B1TAS1R3TAS1R1 | |
| SCHEMBL7884908 | 0.84 | GRIA3 (0.54) | GRIA3GRIA4HSD11B1TAS1R3TAS1R1 | |
| SCHEMBL8105521 | 0.82 | GRIA3 (0.59) | GRIA3GRIA4HSD11B1TAS1R3TAS1R1 | |
| SCHEMBL8114056 | 0.80 | GRIA3 (0.50) | GRIA3GRIA4HSD11B1TAS1R3TAS1R1 | |
| SCHEMBL8107107 | 0.78 | GRIA3 (0.56) | GRIA3GRIA4HSD11B1TAS1R3TAS1R1 | |
| SCHEMBL8107984 | 0.76 | GRIA3 (0.56) | GRIA3GRIA4HSD11B1TAS1R3TAS1R1 | |
| SCHEMBL8114060 | 0.76 | GRIA3 (0.50) | GRIA3GRIA4HSD11B1TAS1R3TAS1R1 | |
| SCHEMBL8108606 | 0.75 | GRIA3 (0.55) | GRIA3GRIA4HSD11B1TAS1R3TAS1R1 | |
| SCHEMBL548631 | 0.74 | GRIA3 (0.53) | GRIA3GRIA4TAS1R3TAS1R1TAS1R2 | |
| SCHEMBL5759402 | 0.74 | GRIA3 (0.72) | GRIA3GRIA4TAS1R3TAS1R1TAS1R2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2233140-A1 | Bicyclic amides for enhancing glutamatergic synaptic responses | Biovail Laboratories International SRL (BB) | 2010-09-29 | — | — | EP | disclosed |
| WO-2009023126-A2 | BICYCLIC AMIDES FOR ENHANCING GLUTAMATERGIC SYNAPTIC RESPONSES | CORTEX PHARMACEUTICALS, INC. (US) | 2009-02-19 | — | — | WO | disclosed |