Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIA3 | P42263 | 1/20 | 0.56 |
| ▸ | GRIA4 | P48058 | 1/20 | 0.56 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.55 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.55 |
| ▸ | TAS1R2 | Q8TE23 | 1/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | TRPC3 | Q13507 | 3/20 | 0.40 |
| ▸ | TRPC6 | Q9Y210 | 3/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | TRPA1 | O75762 | 2/20 | 0.40 |
| ▸ | CACNA1C | Q13936 | 2/20 | 0.40 |
| ▸ | SCN5A | Q14524 | 2/20 | 0.40 |
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.40 |
| ▸ | TRPV4 | Q9HBA0 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8107156 | 0.81 | GRIA3 (0.58) | GRIA3GRIA4TAS1R3TAS1R1TAS1R2 | |
| SCHEMBL8108606 | 0.79 | GRIA3 (0.55) | GRIA3GRIA4TAS1R3TAS1R1TAS1R2 | |
| SCHEMBL7900196 | 0.79 | RAB9A (0.55) | GRIA3GRIA4KMT2A | |
| SCHEMBL7884908 | 0.78 | GRIA3 (0.54) | GRIA3GRIA4TAS1R3TAS1R1TAS1R2 | |
| SCHEMBL8105521 | 0.77 | GRIA3 (0.59) | GRIA3GRIA4TAS1R3TAS1R1TAS1R2 | |
| SCHEMBL5758784 | 0.76 | GRIA3 (0.70) | GRIA3GRIA4TAS1R3TAS1R1TAS1R2 | |
| SCHEMBL8105886 | 0.76 | GRIA3 (0.52) | GRIA3GRIA4TAS1R3TAS1R1TAS1R2 | |
| SCHEMBL548617 | 0.75 | GRIA3 (0.53) | GRIA3GRIA4TAS1R3TAS1R1TAS1R2 | |
| SCHEMBL8114056 | 0.75 | GRIA3 (0.50) | GRIA3GRIA4TAS1R3TAS1R1TAS1R2 | |
| SCHEMBL8114060 | 0.75 | GRIA3 (0.50) | GRIA3GRIA4TAS1R3TAS1R1TAS1R2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2233140-A1 | Bicyclic amides for enhancing glutamatergic synaptic responses | Biovail Laboratories International SRL (BB) | 2010-09-29 | — | — | EP | disclosed |
| WO-2009023126-A2 | BICYCLIC AMIDES FOR ENHANCING GLUTAMATERGIC SYNAPTIC RESPONSES | CORTEX PHARMACEUTICALS, INC. (US) | 2009-02-19 | — | — | WO | disclosed |