Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN1 | P18031 | 2/20 | 0.52 |
| ▸ | PIK3CA | P42336 | 5/20 | 0.47 |
| ▸ | PIK3CD | O00329 | 4/20 | 0.47 |
| ▸ | MTOR | P42345 | 3/20 | 0.46 |
| ▸ | RAB9A | P51151 | 4/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.45 |
| ▸ | NPC1 | O15118 | 3/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | GFER | P55789 | 1/20 | 0.45 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.44 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.44 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 3/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 2/20 | 0.43 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.43 |
| ▸ | CASP3 | P42574 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8101524 | 0.87 | MEN1 (0.54) | PIK3CAPIK3CDMTORRAB9ASMN1; SMN2 | |
| SCHEMBL8093349 | 0.87 | PIK3CD (0.48) | PIK3CAPIK3CDMTORSMN1; SMN2ALDH1A1 | |
| SCHEMBL8106030 | 0.86 | PIK3CA (0.47) | PIK3CAPIK3CDMTORRAB9ASMN1; SMN2 | |
| SCHEMBL8101525 | 0.85 | TP53 (0.51) | PIK3CAPIK3CDMTORRAB9ASMN1; SMN2 | |
| SCHEMBL11925797 | 0.85 | PIK3CA (0.49) | PIK3CAPIK3CDMTORALDH1A1HPGD | |
| SCHEMBL8213955 | 0.85 | PIK3CA (0.53) | PIK3CAPIK3CDMTORLMNA | |
| SCHEMBL8215098 | 0.84 | PIK3CA (0.50) | PIK3CAPIK3CDMTORALDH1A1HPGD | |
| SCHEMBL8104034 | 0.84 | MAPT (0.49) | PIK3CAPIK3CDMTORALDH1A1HPGD | |
| SCHEMBL8103957 | 0.84 | PIK3CD (0.47) | PIK3CAPIK3CDMTORRAB9ASMN1; SMN2 | |
| SCHEMBL8109642 | 0.84 | PIK3CA (0.49) | PIK3CAPIK3CDMTORALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009007749-A2 | TRISUBSTITUTED PYRIMIDINE DERIVATIVES FOR THE TREATMENT OF PROLIFERATIVE DISEASES | ASTRAZENECA AB (SE) | 2009-01-15 | — | — | WO | disclosed |