Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.49 |
| ▸ | PIK3CA | P42336 | 6/20 | 0.47 |
| ▸ | PIK3CD | O00329 | 6/20 | 0.47 |
| ▸ | MTOR | P42345 | 4/20 | 0.46 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.40 |
| ▸ | KDR | P35968 | 2/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.38 |
| ▸ | TUBB | P07437 | 1/20 | 0.38 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.38 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.38 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.38 |
| ▸ | TUBB4B | P68371 | 1/20 | 0.38 |
| ▸ | TUBB3 | Q13509 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8101524 | 0.87 | MEN1 (0.54) | MAPTPIK3CAPIK3CDMTORALDH1A1 | |
| SCHEMBL8093349 | 0.87 | PIK3CD (0.48) | MAPTPIK3CAPIK3CDMTORALDH1A1 | |
| SCHEMBL8101525 | 0.85 | TP53 (0.51) | MAPTPIK3CAPIK3CDMTORALDH1A1 | |
| SCHEMBL11925797 | 0.85 | PIK3CA (0.49) | MAPTPIK3CAPIK3CDMTORALDH1A1 | |
| SCHEMBL8214091 | 0.85 | PIK3CA (0.48) | MAPTPIK3CAPIK3CDMTORALDH1A1 | |
| SCHEMBL8106035 | 0.84 | PTPN1 (0.52) | MAPTPIK3CAPIK3CDMTORALDH1A1 | |
| SCHEMBL8103957 | 0.84 | PIK3CD (0.47) | MAPTPIK3CAPIK3CDMTORALDH1A1 | |
| SCHEMBL8086546 | 0.83 | PIK3CD (0.50) | MAPTPIK3CAPIK3CDMTORALDH1A1 | |
| SCHEMBL8106107 | 0.83 | CA12 (0.49) | MAPTPIK3CAPIK3CDMTORALDH1A1 | |
| SCHEMBL8103980 | 0.83 | PIK3CA (0.47) | MAPTPIK3CAPIK3CDMTORALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009007749-A2 | TRISUBSTITUTED PYRIMIDINE DERIVATIVES FOR THE TREATMENT OF PROLIFERATIVE DISEASES | ASTRAZENECA AB (SE) | 2009-01-15 | — | — | WO | disclosed |